[HTML][HTML] The X-linked histone demethylases KDM5C and KDM6A as regulators of T cell-driven autoimmunity in the central nervous system.
MR Fazazi, GF Ruda, PE Brennan, M Rangachari - Brain Research Bulletin, 2023 - Elsevier
T cell-driven autoimmune responses are subject to striking sex-dependent effects. While the
contributions of sex hormones are well-understood, those of sex chromosomes are meeting …
contributions of sex hormones are well-understood, those of sex chromosomes are meeting …
[HTML][HTML] Myelin-reactive B cells exacerbate CD4+ T cell-driven CNS autoimmunity in an IL-23-dependent manner
MR Fazazi, PMIA Doss, R Pereira, N Fudge… - Nature …, 2024 - nature.com
B cells and T cells collaborate in multiple sclerosis (MS) pathogenesis. IgH [MOG] mice
possess a B cell repertoire skewed to recognize myelin oligodendrocyte glycoprotein …
possess a B cell repertoire skewed to recognize myelin oligodendrocyte glycoprotein …
Biological Sex As a Critical Variable in CD4+ Effector T Cell Function in Preclinical Models of Multiple Sclerosis
M Umair, MR Fazazi, M Rangachari - Antioxidants & Redox …, 2022 - liebertpub.com
Significance: T cells play a pivotal role in maintaining adaptive immune responses against
pathogens. However, misdirected T cell responses against self-tissues may lead to …
pathogens. However, misdirected T cell responses against self-tissues may lead to …
[HTML][HTML] Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity
PMIA Doss, M Umair, J Baillargeon, R Fazazi, N Fudge… - Cell Reports, 2021 - cell.com
Sex differences in multiple sclerosis (MS) incidence and severity have long been
recognized. However, the underlying cellular and molecular mechanisms for why male sex …
recognized. However, the underlying cellular and molecular mechanisms for why male sex …
Role of autoreactive Tc17 cells in the pathogenesis of experimental autoimmune encephalomyelitis
Y Peng, X Zhang, Y Tang, S He, G Rao, Q Chen… - …, 2024 - mednexus.org
Background: The pathogenesis of multiple sclerosis (MS) and experimental autoimmune
encephalomyelitis (EAE—an animal model of MS) is primarily mediated by T cells. However …
encephalomyelitis (EAE—an animal model of MS) is primarily mediated by T cells. However …
Myelin-reactive B cells exacerbate the severity of CD4+ T cell-driven CNS autoimmunity in an IL-23-dependent manner
MR Fazazi, PMI Arokia Doss, R Pereira, N Fudge… - bioRxiv, 2019 - biorxiv.org
Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS) that
has traditionally been considered a T cell-mediated disease. However, accumulating …
has traditionally been considered a T cell-mediated disease. However, accumulating …