Venoms as a platform for human drugs: translating toxins into therapeutics

GF King - Expert opinion on biological therapy, 2011 - Taylor & Francis
Introduction: An extraordinarily diverse range of animals have evolved venoms for predation,
defence, or competitor deterrence. The major components of most venoms are peptides and …

The biology and evolution of spider venoms

T Lüddecke, V Herzig, BM Von Reumont… - Biological …, 2022 - Wiley Online Library
Spiders are diverse, predatory arthropods that have inhabited Earth for around 400 million
years. They are well known for their complex venom systems that are used to overpower …

Animal toxins—Nature's evolutionary-refined toolkit for basic research and drug discovery

V Herzig, B Cristofori-Armstrong, MR Israel… - Biochemical …, 2020 - Elsevier
Venomous animals have evolved toxins that interfere with specific components of their
victim's core physiological systems, thereby causing biological dysfunction that aids in prey …

The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms

BG Fry, K Roelants, DE Champagne… - Annual review of …, 2009 - annualreviews.org
Throughout evolution, numerous proteins have been convergently recruited into the venoms
of various animals, including centipedes, cephalopods, cone snails, fish, insects (several …

Spider-venom peptides: structure, pharmacology, and potential for control of insect pests

GF King, MC Hardy - Annual review of entomology, 2013 - annualreviews.org
Spider venoms are an incredibly rich source of disulfide-rich insecticidal peptides that have
been tuned over millions of years to target a wide range of receptors and ion channels in the …

Spider-venom peptides as therapeutics

NJ Saez, S Senff, JE Jensen, SY Er, V Herzig, LD Rash… - Toxins, 2010 - mdpi.com
Spiders are the most successful venomous animals and the most abundant terrestrial
predators. Their remarkable success is due in large part to their ingenious exploitation of silk …

Spider-venom peptides as bioinsecticides

MJ Windley, V Herzig, SA Dziemborowicz, MC Hardy… - Toxins, 2012 - mdpi.com
Over 10,000 arthropod species are currently considered to be pest organisms. They are
estimated to contribute to the destruction of~ 14% of the world's annual crop production and …

A rational nomenclature for naming peptide toxins from spiders and other venomous animals

GF King, MC Gentz, P Escoubas, GM Nicholson - Toxicon, 2008 - Elsevier
Molecular toxinology research was initially driven by an interest in the small subset of animal
toxins that are lethal to humans. However, the realization that many venomous creatures …

Scorpion venom peptides with no disulfide bridges: a review

A Almaaytah, Q Albalas - Peptides, 2014 - Elsevier
Scorpion venoms are rich sources of biologically active peptides that are classified into
disulfide-bridged peptides (DBPs) and non-disulfide-bridged peptides (NDBPs). DBPs are …

Venomics: a new paradigm for natural products-based drug discovery

I Vetter, JL Davis, LD Rash, R Anangi, M Mobli… - Amino acids, 2011 - Springer
The remarkable potency and pharmacological diversity of animal venoms has made them
an increasingly valuable source of lead molecules for drug and insecticide discovery …