For decades, variability in clinical efficacy of the widely used inflammatory bowel disease
(IBD) drug 5-aminosalicylic acid (5-ASA) has been attributed, in part, to its acetylation and …

Farming and sedentism first appeared in southwestern Asia during the early Holocene and
later spread to neighboring regions, including Europe, along multiple dispersal routes …

We sequenced Early Neolithic genomes from the Zagros region of Iran (eastern Fertile
Crescent), where some of the earliest evidence for farming is found, and identify a previously …

Introduction The N-acetylation polymorphism has been the subject of comprehensive
reviews describing the role of arylamine N-acetyltransferase 2 (NAT2) in the metabolism of …

We present genome-wide data from 40 individuals dating to c. 16,900 to 550 years ago in
northeast Asia. We describe hitherto unknown gene flow and admixture events in the region …

Aim: Humans exhibit genetic polymorphism in NAT2 resulting in rapid, intermediate and
slow acetylator phenotypes. Over 65 NAT2 variants possessing one or more SNPs in the …

Abstract Objective N-acetyltransferase 2 (NAT2) polymorphism could participate in the
metabolism of carcinogens through regulating the activity of a series of critical enzymes …

Purpose This study aims to assess whether NAT2 genotype affects susceptibility to
moderate to severe liver injury in patients undergoing drug treatment for tuberculosis with …

Polymorphisms of N-acetyltransferase 2 (NAT2) are well known to modify urinary bladder
cancer risk as well as efficacy and toxicity of pharmaceuticals via reduction in the enzyme's …

Indirect evidences suggest that acetylation phenotype categories are heterogeneous and
that subcategories, related to specific NAT2 variant alleles might exist. We analyzed the in …