Zebrafish: A model deciphering the impact of flavonoids on neurodegenerative disorders

K Mhalhel, M Sicari, L Pansera, J Chen, M Levanti… - Cells, 2023 - mdpi.com
Over the past century, advances in biotechnology, biochemistry, and pharmacognosy have
spotlighted flavonoids, polyphenolic secondary metabolites that have the ability to modulate …

Small molecule modulators of alpha-synuclein aggregation and toxicity: Pioneering an emerging arsenal against Parkinson's disease

IA Ahanger, TA Dar - Ageing Research Reviews, 2024 - Elsevier
Parkinson's disease (PD) is primarily characterized by loss of dopaminergic neurons in the
substantia nigra pars compacta region of the brain and accumulation of aggregated forms of …

Computational studies applied to flavonoids against Alzheimer's and Parkinson's diseases

AFM Monteiro, JDO Viana, A Nayarisseri… - Oxidative medicine …, 2018 - Wiley Online Library
Neurodegenerative diseases, such as Parkinson's and Alzheimer's, are understood as
occurring through genetic, cellular, and multifactor pathophysiological mechanisms. Several …

Probing the molecular mechanisms of α-synuclein inhibitors unveils promising natural candidates through machine-learning QSAR, pharmacophore modeling, and …

Y Boulaamane, K Jangid, MR Britel, A Maurady - Molecular Diversity, 2024 - Springer
Parkinson's disease is characterized by a multifactorial nature that is linked to different
pathways. Among them, the abnormal deposition and accumulation of α-synuclein fibrils is …

Systematic analysis of the molecular mechanisms mediated by coffee in Parkinson's disease based on network pharmacology approach

F Li, T Hatano, N Hattori - Journal of Functional Foods, 2021 - Elsevier
Many epidemiological studies have associated coffee consumption with a reduced
Parkinson's disease (PD) risk, but the molecular mechanisms remain unclear. In this study …

Prediction of parkinson's disease using machine learning techniques on speech dataset

BK Varghese, D Amali, KS Devi - Research Journal of Pharmacy …, 2019 - indianjournals.com
In the present decade of accelerated advances in Medical Sciences, most studies fail to lay
focus on ageing diseases. These are diseases that display their symptoms at a much …

In Silico Study of Thymohydroquinone Interaction with blood–brain Barrier Disrupting Proteins

FH Shah, S Salman, J Idrees, F Idrees… - Future Science …, 2020 - Taylor & Francis
Aim: To evaluate the inhibitory interaction of thymohydroquinone against blood–brain barrier
(BBB)-associated neuropsychiatric and neurodegenerative disorders. Materials & methods …

[HTML][HTML] A Network Pharmacology Identified Metastasis Target for Oral Squamous Cell Carcinoma Originating from Breast Cancer with a Potential Inhibitor from F …

A Alqarni, J Hosmani, S Alassiri… - …, 2024 - pmc.ncbi.nlm.nih.gov
This study aimed to identify specific therapeutic targets for oral squamous cell carcinoma
(OSCC) that metastasize from breast cancer (BC) by using network pharmacology. The …

Design, in-silico ADME Study and molecular docking study of novel quinoline-4-on derivatives as Factor Xa Inhibitor as Potential anti-coagulating agents

N Patadiya, V Vaghela - Asian Journal of Pharmaceutical …, 2022 - indianjournals.com
The main aim of present work is to identification of potency of novel quinoline-4-one
derivatives as a factor Xa inhibitors by in-silico ADME study and molecular docking study …

Recent Plant Based Remedies for Alzheimer's Disease, Parkinson's Disease and Cerebral Ischemic Stroke

P Thomas, S Jeyarani, T Choephel… - Research Journal of …, 2019 - indianjournals.com
Neurological disorders such as Alzheimer's Disease (AD), Parkinsons's Disease (PD) and
Cerebral Ischemic Stroke (CIS) are responsible for morbidities in almost a billion people and …