Subthalamic control of impulsive actions: insights from deep brain stimulation in Parkinson's disease

DM Herz, MJ Frank, H Tan, S Groppa - Brain, 2024 - academic.oup.com
Control of actions allows adaptive, goal-directed behaviour. The basal ganglia, including the
subthalamic nucleus, are thought to play a central role in dynamically controlling actions …

Perspectives of implementation of closed-Loop Deep Brain Stimulation: from neurological to Psychiatric disorders

S Groppa, G Gonzalez-Escamilla, G Tinkhauser… - 2023 - karger.com
Background: Deep brain stimulation (DBS) is a highly efficient, evidence-based therapy to
alleviate symptoms and improve quality of life in movement disorders such as ParkinsonLs …

Effort cost of harvest affects decisions and movement vigor of marmosets during foraging

P Hage, IK Jang, V Looi, MA Fakharian, SP Orozco… - Elife, 2023 - elifesciences.org
Our decisions are guided by how we perceive the value of an option, but this evaluation also
affects how we move to acquire that option. Why should economic variables such as reward …

Task goals shape the relationship between decision and movement speed

F Fievez, I Cos, T Carsten… - Journal of …, 2024 - journals.physiology.org
The speed at which we move is linked to the speed at which we decide to make these
movements. Yet, the principles guiding such relationship remain unclear: while some …

Subthalamic stimulation modulates context-dependent effects of beta bursts during fine motor control

M Bange, G Gonzalez-Escamilla, DM Herz… - Nature …, 2024 - nature.com
Increasing evidence suggests a considerable role of pre-movement beta bursts for motor
control and its impairment in Parkinson's disease. However, whether beta bursts occur …

Dynamic modulation of subthalamic nucleus activity facilitates adaptive behavior

DM Herz, M Bange, G Gonzalez-Escamilla, M Auer… - PLoS …, 2023 - journals.plos.org
Adapting actions to changing goals and environments is central to intelligent behavior.
There is evidence that the basal ganglia play a crucial role in reinforcing or adapting actions …

Neuroscience: Therapy modulates decision-making in Parkinson's disease

DM Herz - Current Biology, 2024 - cell.com
There is mounting evidence that decision-making can be affected by treatment in
Parkinson's disease. A new study shows that dopamine and deep brain stimulation, two …

Integrated control of non-motor and motor efforts during perceptual decision-making and action execution: A pilot study

É Leroy, É Koun, D Thura - Scientific Reports, 2023 - nature.com
Humans daily life is characterized by a succession of voluntary actions. Since energy
resources are limited, the ability to invest the appropriate amount of effort for selecting and …

Evidence for interacting but decoupled controls of decisions and movements in nonhuman primates

C Saleri, D Thura - Journal of Neurophysiology, 2024 - journals.physiology.org
Many recent studies indicate that control of decisions and actions is integrated during
interactive behavior. Among these, several carried out in humans and monkeys conclude …

[HTML][HTML] Concurrent inflammation-related brain reorganization in multiple sclerosis and depression

LSM Galindo, G Gonzalez-Escamilla… - Brain, Behavior, and …, 2024 - Elsevier
Background Neuroinflammation affects brain tissue integrity in multiple sclerosis (MS) and
may have a role in major depressive disorder (MDD). Whether advanced magnetic …