Osteoblasts, the cells that build up our skeleton, are remarkably versatile and important cells
that need tight regulation in all the phases of their differentiation to guarantee proper skeletal …

In the recent years, a paradigm shift is taking place where metallic/synthetic implants and
tissue grafts are being replaced by tissue engineering approach. A well designed three …

Bone tissue regeneration is augmented by biocompatible nanofiber scaffolds, that supports
reliable and enhanced bone formation. Zinc is an essential mineral that is vital for routine …

The bone fracture cases have been increasing yearly, accompanied by the increased
number of patients experiencing non-union or delayed union after their bone fracture …

Runx2 is a master transcription factor for osteogenesis. The most important phenomenon
that makes this protein a master regulator for osteogenesis is its structural integrity. In …

Background Bone loss during trauma, surgeries, and tumor resection often results in critical-
sized bone defects that need to be filled with substitutionary materials. Complications …

Osteoporosis and sarcopenia are two age-related diseases that affect the quality of life in the
elderly. Initially, they were thought to be two independent diseases; however, recently …

Bone is one of the most dynamic organs in the body that continuously undergoes
remodeling through bone formation and resorption. A cascade of molecules and pathways …

Extracellular vesicles (EVs) are emerging in tissue engineering as promising acellular tools,
circumventing many of the limitations associated with cell‐based therapies. Epigenetic …

Biochemical markers of bone turnover have been used for decades in the management of
bone diseases, to assess the prognosis of these conditions and to monitor treatments. The …