From belly to brain: targeting the ghrelin receptor in appetite and food intake regulation

K Howick, BT Griffin, JF Cryan… - International journal of …, 2017 - mdpi.com
Ghrelin is the only known peripherally-derived orexigenic hormone, increasing appetite and
subsequent food intake. The ghrelinergic system has therefore received considerable …

Mechanisms in endocrinology: Ghrelin: the differences between acyl-and des-acyl ghrelin

PJD Delhanty, SJ Neggers… - European journal of …, 2012 - academic.oup.com
Des-acyl ghrelin (DAG) is one of the three preproghrelin gene-encoded peptides. Compared
with ghrelin and obestatin, it has not received the attention it deserves. DAG has long been …

Ghrelin's relationship to blood glucose

BK Mani, K Shankar, JM Zigman - Endocrinology, 2019 - academic.oup.com
Much effort has been directed at studying the orexigenic actions of administered ghrelin and
the potential effects of the endogenous ghrelin system on food intake, food reward, body …

Microbial endocrinology: host–bacteria communication within the gut microbiome

S Sandrini, M Aldriwesh, M Alruways… - Journal of …, 2015 - joe.bioscientifica.com
Isolated maternal hypothyroxinemia (IMH) during pregnancy is defined as a low maternal T
4 in the absence of TSH elevation. As IMH is common, with a prevalence of 1–2% in iodine …

Des-acyl ghrelin: a metabolically active peptide

PJ Delhanty, SJ Neggers, AJ van der Lely - The Ghrelin System, 2013 - karger.com
Unacylated ghrelin (UAG), or des-acyl ghrelin, is slowly fighting its way up into the field of
interest that studies preproghrelin gene-encoded peptides. Long considered to be an inert …

Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors

KM Heppner, CL Piechowski, A Müller, N Ottaway… - Diabetes, 2014 - Am Diabetes Assoc
Growth hormone secretagogue receptors (GHSRs) in the central nervous system (CNS)
mediate hyperphagia and adiposity induced by acyl ghrelin (AG). Evidence suggests that …

Ghrelin regulation of glucose metabolism

SM Gray, LC Page, J Tong - Journal of neuroendocrinology, 2019 - Wiley Online Library
Ghrelin and its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), are
implicated in the regulation of glucose metabolism via direct actions in the pancreatic islet …

The human experience with ghrelin administration

MC Garin, CM Burns, S Kaul… - The Journal of Clinical …, 2013 - academic.oup.com
Context: Ghrelin is an endogenous stimulator of GH and is implicated in a number of
physiological processes. Clinical trials have been performed in a variety of patient …

[HTML][HTML] Interrelationships between ghrelin, insulin and glucose homeostasis: physiological relevance

F Chabot, A Caron, M Laplante… - World journal of …, 2014 - ncbi.nlm.nih.gov
Ghrelin is a 28 amino acid peptide mainly derived from the oxyntic gland of the stomach.
Both acylated (AG) and unacylated (UAG) forms of ghrelin are found in the circulation …

Ghrelin as a biomarker of “immunometabolic depression” and its connection with dysbiosis

A Gajewska, D Strzelecki, O Gawlik-Kotelnicka - Nutrients, 2023 - mdpi.com
Ghrelin, a gastrointestinal peptide, is an endogenous ligand of growth hormone
secretagogue receptor 1a (GHSR1a), which is mainly produced by X/A-like cells in the …