Doxorubicin (DOX) constitutes the major constituent of anti-cancer treatment regimens
currently in clinical use. However, the precise mechanisms of DOX's action are not fully …

Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …

Induction of immunogenic cell death (ICD) in tumor combined with immune checkpoint
blockade (ICB) therapy is widely developed to improve the efficacy of cancer …

Prostate cancer (PCa) is a frustrating immunogenic “cold” tumor and generally receives
unsatisfied immunotherapy outcomes in the clinic. Pyroptosis is an excellent immunogenic …

The application of immunotherapy for cancer treatment is rapidly becoming more
widespread. Immunotherapeutic agents are frequently combined with various types of …

Rationale: An immunosuppressive tumor microenvironment (TME) is a major obstacle in
tumor immunotherapy. Stimulator of interferon genes (STING) agonists trigger an …

Pyroptosis differs significantly from apoptosis and cell necrosis as an alternative mode of
programmed cell death. Its occurrence is mediated by the gasdermin protein, leading to …

As advances in high-resolution single-cell technology shed light on the complex
microenvironment of tumors, the focus of clinical strategies has shifted to single-cell …

Drug resistance represents a significant obstacle in cancer treatment, underscoring the need
for the discovery of novel therapeutic targets. Ubiquitin-specific proteases (USPs), a …

Background The interaction between pyroptosis—a form of programmed cell death—and
tumor immunity represents a burgeoning field of interest. Pyroptosis exhibits a dual role in …