Claudins are a family of tight junction membrane proteins that regulate paracellular
permeability of epithelia, likely by forming the lining of the paracellular pore. Claudins are …

The extraordinarily thin alveolar type 1 (AT1) cell constitutes nearly the entire gas exchange
surface and allows passive diffusion of oxygen into the blood stream. Despite such an …

Purpose Fiber cells of the ocular lens are bounded by a highly specialized plasma
membrane. Despite the pivotal role that membrane proteins play in the physiology and …

In this paper, we introduce Gene Knockout Inference (GenKI), a virtual knockout (KO) tool for
gene function prediction using single-cell RNA sequencing (scRNA-seq) data in the …

Mitochondrial antiviral signaling protein (MAVS) and stimulator of interferon (IFN) genes
(STING) are crucial factors of IFN induction in RNA and DNA viral infections. However …

The claudin family of integral membrane proteins was identified as the major protein
component of the tight junctions in all vertebrates. Since their identification, claudins, and …

Apoptosis triggered by exogenous or endogenous stimuli is a crucial phenomenon to
determine the fate of neurons, both in physiological and in pathological conditions. Our …

Background: TMEM47 is the vertebrate orthologue of C. elegans VAB‐9, a tetraspan
adherens junction protein in the PMP22/EMP/Claudin family of proteins. VAB‐9 regulates …

The Tmhs gene codes for a tetraspan transmembrane protein that is expressed in hair cell
stereocilia. We previously showed that a spontaneous missense mutation of Tmhs underlies …

In the last decade, the claudin family of integral membrane proteins has been identified as
the major protein component of the tight junctions in all vertebrates. The claudin superfamily …