Although platelets are widely recognized as having a critical role in primary hemostasis and
thrombosis, increasing experimental and clinical evidence identifies these enucleated cells …

Optimal fracture treatment requires knowledge of the complex physiological process of bone
healing. The course of bone healing is mainly influenced by fracture fixation stability …

Osteogenesis during bone modeling and remodeling is coupled with angiogenesis. A recent
study showed that a specific vessel subtype, strongly positive for CD31 and endomucin …

The transforming growth factor beta (TGF‐β) family forms a group of three isoforms, TGF‐β1,
TGF‐β2, and TGF‐β3, with their structure formed by interrelated dimeric polypeptide chains …

The treatment of craniofacial defects can present many challenges due to the variety of
tissue-specific requirements and the complexity of anatomical structures in that region. 3D …

Prior preclinical and clinical studies support the use of platelet-derived products for the
treatment of soft and hard tissue lesions. These regenerative effects are controlled by …

Rise in the incidences of chronic degenerative diseases with aging makes wound care a
socio-economic burden and unceasingly necessitates a novel, economical, and efficient …

Several biomaterials can be obtained from human blood. Some are used for clinical
indications requiring a high content in fibrinogen, while others are used because they …

Despite the popularity of platelet-rich plasma (PRP) and platelet lysate (PL) in orthopaedic
practice, the mechanism of action and the effectiveness of these therapeutic tools are still …

Bone regeneration represents a complex process, of which basic biologic principles have
been evolutionarily conserved over a broad range of different species. Bone represents one …