Dendritic cells as shepherds of T cell immunity in cancer
In cancer patients, dendritic cells (DCs) in tumor-draining lymph nodes can present antigens
to naive T cells in ways that break immunological tolerance. The clonally expanded progeny …
to naive T cells in ways that break immunological tolerance. The clonally expanded progeny …
Genetic models of human and mouse dendritic cell development and function
Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …
numerous shared characteristics between mice and humans. Human counterparts of mouse …
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
AR Pombo Antunes, I Scheyltjens, F Lodi… - Nature …, 2021 - nature.com
Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors.
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …
Transcriptional basis of mouse and human dendritic cell heterogeneity
CC Brown, H Gudjonson, Y Pritykin, D Deep… - Cell, 2019 - cell.com
Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to
their unique ability to initiate T cell responses and direct their differentiation into effector …
their unique ability to initiate T cell responses and direct their differentiation into effector …
Dendritic cells revisited
M Cabeza-Cabrerizo, A Cardoso… - Annual review of …, 2021 - annualreviews.org
Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a …
communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a …
Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses
KL Hilligan, F Ronchese - Cellular & molecular immunology, 2020 - nature.com
Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …
Monocytes, macrophages, dendritic cells and neutrophils: an update on lifespan kinetics in health and disease
Phagocytes form a family of immune cells that play a crucial role in tissue maintenance and
help orchestrate the immune response. This family of cells can be separated by their nuclear …
help orchestrate the immune response. This family of cells can be separated by their nuclear …
The role of dendritic cells in cancer and anti-tumor immunity
AE Marciscano, N Anandasabapathy - Seminars in immunology, 2021 - Elsevier
Dendritic cells (DC) are key sentinels of the host immune response with an important role in
linking innate and adaptive immunity and maintaining tolerance. There is increasing …
linking innate and adaptive immunity and maintaining tolerance. There is increasing …
LXR signaling controls homeostatic dendritic cell maturation
V Bosteels, S Maréchal, C De Nolf, S Rennen… - Science …, 2023 - science.org
Dendritic cells (DCs) mature in an immunogenic or tolerogenic manner depending on the
context in which an antigen is perceived, preserving the balance between immunity and …
context in which an antigen is perceived, preserving the balance between immunity and …
Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells
Developmental origins of dendritic cells (DCs) including conventional DCs (cDCs,
comprising cDC1 and cDC2 subsets) and plasmacytoid DCs (pDCs) remain unclear. We …
comprising cDC1 and cDC2 subsets) and plasmacytoid DCs (pDCs) remain unclear. We …