Dendritic cells as shepherds of T cell immunity in cancer

MJ Pittet, M Di Pilato, C Garris, TR Mempel - Immunity, 2023 - cell.com
In cancer patients, dendritic cells (DCs) in tumor-draining lymph nodes can present antigens
to naive T cells in ways that break immunological tolerance. The clonally expanded progeny …

Genetic models of human and mouse dendritic cell development and function

DA Anderson III, CA Dutertre, F Ginhoux… - Nature Reviews …, 2021 - nature.com
Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

AR Pombo Antunes, I Scheyltjens, F Lodi… - Nature …, 2021 - nature.com
Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors.
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …

Transcriptional basis of mouse and human dendritic cell heterogeneity

CC Brown, H Gudjonson, Y Pritykin, D Deep… - Cell, 2019 - cell.com
Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to
their unique ability to initiate T cell responses and direct their differentiation into effector …

Dendritic cells revisited

M Cabeza-Cabrerizo, A Cardoso… - Annual review of …, 2021 - annualreviews.org
Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a …

Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses

KL Hilligan, F Ronchese - Cellular & molecular immunology, 2020 - nature.com
Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …

Monocytes, macrophages, dendritic cells and neutrophils: an update on lifespan kinetics in health and disease

AA Patel, F Ginhoux, S Yona - Immunology, 2021 - Wiley Online Library
Phagocytes form a family of immune cells that play a crucial role in tissue maintenance and
help orchestrate the immune response. This family of cells can be separated by their nuclear …

The role of dendritic cells in cancer and anti-tumor immunity

AE Marciscano, N Anandasabapathy - Seminars in immunology, 2021 - Elsevier
Dendritic cells (DC) are key sentinels of the host immune response with an important role in
linking innate and adaptive immunity and maintaining tolerance. There is increasing …

LXR signaling controls homeostatic dendritic cell maturation

V Bosteels, S Maréchal, C De Nolf, S Rennen… - Science …, 2023 - science.org
Dendritic cells (DCs) mature in an immunogenic or tolerogenic manner depending on the
context in which an antigen is perceived, preserving the balance between immunity and …

Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells

J Feng, JN Pucella, G Jang, M Alcántara-Hernández… - Immunity, 2022 - cell.com
Developmental origins of dendritic cells (DCs) including conventional DCs (cDCs,
comprising cDC1 and cDC2 subsets) and plasmacytoid DCs (pDCs) remain unclear. We …