Molecular diversity of glutamate receptors and implications for brain function
S Nakanishi - Science, 1992 - science.org
The glutamate receptors mediate excitatory neurotransmission in the brain and are
important in memory acquisition, learning, and some neurodegenerative disorders. This …
important in memory acquisition, learning, and some neurodegenerative disorders. This …
[HTML][HTML] Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
A Taly, PJ Corringer, D Guedin, P Lestage… - Nature reviews Drug …, 2009 - nature.com
Nicotinic receptors—a family of ligand-gated ion channels that mediate the effects of the
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …
Crystal structure of a heterotetrameric NMDA receptor ion channel
E Karakas, H Furukawa - Science, 2014 - science.org
N-Methyl-d-aspartate (NMDA) receptors belong to the family of ionotropic glutamate
receptors, which mediate most excitatory synaptic transmission in mammalian brains …
receptors, which mediate most excitatory synaptic transmission in mammalian brains …
Agonist selectivity and ion permeation in the α3β4 ganglionic nicotinic receptor
Nicotinic acetylcholine receptors are pentameric ion channels that mediate fast chemical
neurotransmission. The α3β4 nicotinic receptor subtype forms the principal relay between …
neurotransmission. The α3β4 nicotinic receptor subtype forms the principal relay between …
Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution
N Unwin - Journal of molecular biology, 2005 - Elsevier
We present a refined model of the membrane-associated Torpedo acetylcholine (ACh)
receptor at 4Å resolution. An improved experimental density map was obtained from 342 …
receptor at 4Å resolution. An improved experimental density map was obtained from 342 …
[HTML][HTML] Structural principles of distinct assemblies of the human α4β2 nicotinic receptor
Fast chemical communication in the nervous system is mediated by neurotransmitter-gated
ion channels. The prototypical member of this class of cell surface receptors is the cation …
ion channels. The prototypical member of this class of cell surface receptors is the cation …
[HTML][HTML] Structure and gating mechanism of the acetylcholine receptor pore
A Miyazawa, Y Fujiyoshi, N Unwin - Nature, 2003 - nature.com
The nicotinic acetylcholine receptor controls electrical signalling between nerve and muscle
cells by opening and closing a gated, membrane-spanning pore. Here we present an atomic …
cells by opening and closing a gated, membrane-spanning pore. Here we present an atomic …
Molecular cloning and characterization of the rat NMDA receptor
A complementary DNA encoding the rat NMDA receptor has been cloned and characterized.
The single protein encoded by the cDNA forms a receptor-channel complex that has …
The single protein encoded by the cDNA forms a receptor-channel complex that has …
Molecular structure and function of the glycine receptor chloride channel
JW Lynch - Physiological reviews, 2004 - journals.physiology.org
The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …
Membrane protein folding and oligomerization: the two-stage model
JL Popot, DM Engelman - Biochemistry, 1990 - ACS Publications
Instituí de Biologie Physico-Chimique and College de France, 13 rue Pierre et Marie Curie,
F-75005 Paris, France, and Department of Molecular Biophysicsand Biochemistry, Yale …
F-75005 Paris, France, and Department of Molecular Biophysicsand Biochemistry, Yale …