HIV-1 protease inhibitors continue to play an important role in the treatment of HIV/AIDS,
transforming this deadly ailment into a more manageable chronic infection. Over the years …

Proteases form one of the largest and more important groups of enzymes. They selectively
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …

The human immunodeficiency virus (HIV) genome encodes a total of three structural
proteins, two envelope proteins, three enzymes, and six accessory proteins. Studies over the …

The crystal structure of the protease of the human immunodeficiency virus type 1 (HIV-1),
which releases structural proteins and enzymes from viral polyprotein products, has been …

A nuclear encoded mitochondrial heat-shock protein hsp60 is required for the assembly into
oligomeric complexes of proteins imported into the mitochondrial matrix. hsp60 is a member …

In the past dozen years, our understanding of the structure and function of the aspartic
proteinases has increased greatly. We have made spectacular progress in determining …

The effects on human immunodeficiency virus type 1 virion morphogenesis and on virus
replication of mutations that affect posttranslational processing of the capsid precursor …

US5519126A - Oligonucleotide N-alkylphosphoramidates - Google Patents US5519126A -
Oligonucleotide N-alkylphosphoramidates - Google Patents Oligonucleotide N-alkylphosphoramidates …

least four activities:(a) protease (PR),(b) the polymerase and (c) nuclease H (RNase H)
activities of reverse transcriptase (RT), and integrase (IN). These activities are required for …

Curcumin, a relatively non-toxic natural product isolated from Curcuma longa, is a modest
inhibitor of the HIV-1 (1050= 100 μM) and HIV-2 (IC 50= 250 μM) proteases. Simple …