A decline in energy is common in aging, and the restoration of mitochondrial bioenergetics
may offer a common approach for the treatment of numerous age‐associated diseases …

The first suggestion that physical exercise results in free radical-mediated damage to tissues
appeared in 1978, and the past three decades have resulted in a large growth of knowledge …

Rationale: Diaphragm dysfunction worsens outcomes in mechanically ventilated patients,
but the clinical impact of potentially preventable changes in diaphragm structure and …

Several mechanisms of diaphragm muscle injury (myotrauma) can result in ventilator-
induced diaphragm dysfunction, including ventilator over-assistance, under-assistance …

Background The combination of complete diaphragm inactivity and mechanical ventilation
(for more than 18 hours) elicits disuse atrophy of myofibers in animals. We hypothesized that …

The act of breathing depends on coordinated activity of the respiratory muscles to generate
subatmospheric pressure. This action is compromised by disease states affecting …

Mechanical ventilation is a life-saving form of supportive therapy for respiratory failure. In
addition to support of gas exchange, other potential benefits of mechanical ventilation …

The diaphragm is the main inspiratory muscle, and its dysfunction can lead to significant
adverse clinical consequences. The aim of this review is to provide clinicians with an …

Rationale: The clinical significance of diaphragm weakness in critically ill patients is evident:
it prolongs ventilator dependency, and increases morbidity and duration of hospital stay. To …

Key points Oxidative stress is widely considered a major cause of muscle loss not only in
disuse but also in most chronic diseases, triggering carbonylation of proteins and activation …