The complex role of adipokines in obesity, inflammation, and autoimmunity

EB Taylor - Clinical Science, 2021 - portlandpress.com
The global obesity epidemic is a major contributor to chronic disease and disability in the
world today. Since the discovery of leptin in 1994, a multitude of studies have characterized …

Chemerin: at the crossroads of inflammation and obesity

MC Ernst, CJ Sinal - Trends in Endocrinology & Metabolism, 2010 - cell.com
Chemerin is a secreted protein with a complex but well-established role in immune function.
Parallel lines of investigation also support the notion that chemerin is a novel adipokine that …

[HTML][HTML] Pathogenic role of IL-17-producing immune cells in obesity, and related inflammatory diseases

M Chehimi, H Vidal, A Eljaafari - Journal of clinical medicine, 2017 - mdpi.com
Obesity is associated with low-grade chronic inflammation. Indeed, adipose tissues (AT) in
obese individuals are the former site of progressive infiltration by pro-inflammatory immune …

Towards an integrative approach to understanding the role of chemerin in human health and disease

JL Rourke, HJ Dranse, CJ Sinal - Obesity Reviews, 2013 - Wiley Online Library
Chemerin is an adipocyte‐secreted protein with autocrine/paracrine roles on adipose
development and function as well as endocrine roles in metabolism and immunity. Following …

Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism

B Bondue, V Wittamer, M Parmentier - Cytokine & growth factor reviews, 2011 - Elsevier
Chemerin was isolated as the natural ligand of the G protein-coupled receptor ChemR23.
Chemerin acts as a chemotactic factor for leukocyte populations expressing ChemR23 …

[HTML][HTML] N-3 polyunsaturated fatty acids and the resolution of neuroinflammation

C Joffre, C Rey, S Layé - Frontiers in pharmacology, 2019 - frontiersin.org
In the past few decades, as a result of their anti-inflammatory properties, n-3 long chain
polyunsaturated fatty acids (n-3 LC-PUFAs), have gained greater importance in the …

International union of basic and clinical pharmacology CIII: chemerin receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) nomenclature, pharmacology, and …

AJ Kennedy, AP Davenport - Pharmacological Reviews, 2018 - ASPET
Chemerin, a chemoattractant protein and adipokine, has been identified as the endogenous
ligand for a G protein–coupled receptor encoded by the gene CMKLR1 (also known as …

[HTML][HTML] Multiple sclerosis and obesity: The role of adipokines

J Correale, M Marrodan - Frontiers in immunology, 2022 - frontiersin.org
Multiple Sclerosis (MS), a chronic inflammatory disease of the central nervous system that
leads to demyelination and neurodegeneration has been associated with various …

Multiple sclerosis and obesity: possible roles of adipokines

JJ Guerrero-García, L Carrera-Quintanar… - Mediators of …, 2016 - Wiley Online Library
Multiple Sclerosis (MS) is an autoimmune disorder of the Central Nervous System that has
been associated with several environmental factors, such as diet and obesity. The possible …

Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance

MC Ernst, ID Haidl, LA Zúñiga, HJ Dranse… - …, 2012 - academic.oup.com
Adipose tissue secretes a variety of bioactive signaling molecules, termed adipokines, which
regulate numerous biological functions including appetite, energy balance, glucose …