The nuclear lamins: flexibility in function
B Burke, CL Stewart - Nature reviews Molecular cell biology, 2013 - nature.com
The nuclear lamina is an important structural determinant for the nuclear envelope as a
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
Research in cellular mechanotransduction often focuses on how extracellular physical
forces are converted into chemical signals at the cell surface. However, mechanical forces …
forces are converted into chemical signals at the cell surface. However, mechanical forces …
A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells
We have developed a new technique for proximity-dependent labeling of proteins in
eukaryotic cells. Named BioID for proximity-dependent biotin identification, this approach is …
eukaryotic cells. Named BioID for proximity-dependent biotin identification, this approach is …
DNA cross-bridging shapes a single nucleus from a set of mitotic chromosomes
M Samwer, MWG Schneider, R Hoefler… - Cell, 2017 - cell.com
Eukaryotic cells store their chromosomes in a single nucleus. This is important to maintain
genomic integrity, as chromosomes packaged into separate nuclei (micronuclei) are prone …
genomic integrity, as chromosomes packaged into separate nuclei (micronuclei) are prone …
Nuclear structure in cancer cells
D Zink, AH Fischer, JA Nickerson - Nature reviews cancer, 2004 - nature.com
Nuclear architecture—the spatial arrangement of chromosomes and other nuclear
components—provides a framework for organizing and regulating the diverse functional …
components—provides a framework for organizing and regulating the diverse functional …
The nuclear lamina comes of age
Y Gruenbaum, A Margalit, RD Goldman… - … reviews Molecular cell …, 2005 - nature.com
Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins,
nesprins and SUN-domain proteins. These complexes have roles in chromatin organization …
nesprins and SUN-domain proteins. These complexes have roles in chromatin organization …
LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation
During cell division, remodelling of the nuclear envelope enables chromosome segregation
by the mitotic spindle. The reformation of sealed nuclei requires ESCRTs (endosomal …
by the mitotic spindle. The reformation of sealed nuclei requires ESCRTs (endosomal …
Nesprin-1 and-2 are involved in the pathogenesis of Emery–Dreifuss muscular dystrophy and are critical for nuclear envelope integrity
Q Zhang, C Bethmann, NF Worth… - Human molecular …, 2007 - academic.oup.com
Emery–Dreifuss muscular dystrophy (EDMD) is a heterogeneous late-onset disease
involving skeletal muscle wasting and heart defects caused, in a minority of cases, by …
involving skeletal muscle wasting and heart defects caused, in a minority of cases, by …
Repair of nuclear ruptures requires barrier-to-autointegration factor
CT Halfmann, RM Sears, A Katiyar… - Journal of Cell …, 2019 - rupress.org
Cell nuclei rupture following exposure to mechanical force and/or upon weakening of
nuclear integrity, but nuclear ruptures are repairable. Barrier-to-autointegration factor (BAF) …
nuclear integrity, but nuclear ruptures are repairable. Barrier-to-autointegration factor (BAF) …
Nuclear lamins: building blocks of nuclear architecture
RD Goldman, Y Gruenbaum, RD Moir… - Genes & …, 2002 - genesdev.cshlp.org
Nuclear lamins were initially identified as the major components of the nuclear lamina, a
proteinaceous layer found at the interface between chromatin and the inner nuclear …
proteinaceous layer found at the interface between chromatin and the inner nuclear …