The nuclear lamina is an important structural determinant for the nuclear envelope as a
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …

Research in cellular mechanotransduction often focuses on how extracellular physical
forces are converted into chemical signals at the cell surface. However, mechanical forces …

We have developed a new technique for proximity-dependent labeling of proteins in
eukaryotic cells. Named BioID for proximity-dependent biotin identification, this approach is …

Eukaryotic cells store their chromosomes in a single nucleus. This is important to maintain
genomic integrity, as chromosomes packaged into separate nuclei (micronuclei) are prone …

Nuclear architecture—the spatial arrangement of chromosomes and other nuclear
components—provides a framework for organizing and regulating the diverse functional …

Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins,
nesprins and SUN-domain proteins. These complexes have roles in chromatin organization …

During cell division, remodelling of the nuclear envelope enables chromosome segregation
by the mitotic spindle. The reformation of sealed nuclei requires ESCRTs (endosomal …

Emery–Dreifuss muscular dystrophy (EDMD) is a heterogeneous late-onset disease
involving skeletal muscle wasting and heart defects caused, in a minority of cases, by …

Cell nuclei rupture following exposure to mechanical force and/or upon weakening of
nuclear integrity, but nuclear ruptures are repairable. Barrier-to-autointegration factor (BAF) …

Nuclear lamins were initially identified as the major components of the nuclear lamina, a
proteinaceous layer found at the interface between chromatin and the inner nuclear …