1NHS Blood and Transplant, 2Imperial College Healthcare NHS Trust, London, 3University
College Hospitals NHS Trust, London, 4Serious Hazards of Transfusion, NHS Blood and …

Efforts to create platelet-like structures for the augmentation of haemostasis have focused
solely on recapitulating aspects of platelet adhesion; more complex platelet behaviours such …

BACKGROUND: Bleeding is one of the commonest complications affecting children
undergoing cardiac surgery on cardiopulmonary bypass. Antifibrinolytic drugs are part of a …

Congenital heart disease is the commonest birth defect, and advances in modern medicine
mean 90% of these children now survive to adulthood. Therefore, many children present to …

OBJECTIVES: Recent studies suggest adverse events associated with aprotinin in adults
may not occur in children, and there is interest in further pediatric study of aprotinin …

Objective: Tranexamic acid (TXA) and ɛ-aminocaproic acid (EACA) are used for
antifibrinolytic therapy in cardiac surgery, although data directly comparing their blood …

Objective Children undergoing congenital cardiac surgery (CCS) are at increased risk for
acute kidney injury (AKI) due to a number of factors. Recent evidence suggests AKI may …

OBJECTIVE: Deep hypothermic circulatory arrest (DHCA) and antegrade cerebral perfusion
(ACP) are 2 cardiopulmonary bypass techniques applied in aortic arch repair. In recent …

OBJECTIVE: Factors contributing to postoperative complications include blood loss and a
heightened inflammatory response. The objective of this study was to test the hypothesis that …

BACKGROUND: Aprotinin was used frequently in children undergoing congenital heart
operations with the aim of reducing bleeding, until it was taken off the market after adult …