[HTML][HTML] Plant molecular farming for the production of valuable proteins–Critical evaluation of achievements and future challenges
S Schillberg, R Finnern - Journal of plant physiology, 2021 - Elsevier
Recombinant proteins play an important role in many areas of our lives. For example,
recombinant enzymes are used in the food and chemical industries and as high-quality …
recombinant enzymes are used in the food and chemical industries and as high-quality …
[HTML][HTML] Vaccine-associated enhanced disease and pathogenic human coronaviruses
Vaccine-associated enhanced disease (VAED) is a difficult phenomenon to define and can
be confused with vaccine failure. Using studies on respiratory syncytial virus (RSV) …
be confused with vaccine failure. Using studies on respiratory syncytial virus (RSV) …
[HTML][HTML] A role for Fc function in therapeutic monoclonal antibody-mediated protection against Ebola virus
The recent Ebola virus (EBOV) epidemic highlighted the need for effective vaccines and
therapeutics to limit and prevent outbreaks. Host antibodies against EBOV are critical for …
therapeutics to limit and prevent outbreaks. Host antibodies against EBOV are critical for …
Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
The 2015–2016 outbreak of Zika virus (ZIKV) disease has affected many countries and is a
major public health concern. ZIKV is associated with fetal microcephaly and neurological …
major public health concern. ZIKV is associated with fetal microcephaly and neurological …
[HTML][HTML] Ebola virus disease: An emerging and re-emerging viral threat
The genus Ebolavirus from the family Filoviridae is composed of five species including
Sudan ebolavirus, Reston ebolavirus, Bundibugyo ebolavirus, Taï Forest ebolavirus, and …
Sudan ebolavirus, Reston ebolavirus, Bundibugyo ebolavirus, Taï Forest ebolavirus, and …
Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open …
MR Gaudinski, EE Coates, L Novik, A Widge… - The Lancet, 2019 - thelancet.com
Background mAb114 is a single monoclonal antibody that targets the receptor-binding
domain of Ebola virus glycoprotein, which prevents mortality in rhesus macaques treated …
domain of Ebola virus glycoprotein, which prevents mortality in rhesus macaques treated …
[HTML][HTML] Post-exposure treatments for Ebola and Marburg virus infections
RW Cross, CE Mire, H Feldmann… - Nature Reviews Drug …, 2018 - nature.com
The filoviruses—Ebola virus and Marburg virus—cause lethal haemorrhagic fever in
humans and non-human primates (NHPs). Filoviruses present a global health threat both as …
humans and non-human primates (NHPs). Filoviruses present a global health threat both as …
[HTML][HTML] Development of a human antibody cocktail that deploys multiple functions to confer pan-ebolavirus protection
Passive administration of monoclonal antibodies (mAbs) is a promising therapeutic
approach for Ebola virus disease (EVD). However, all mAbs and mAb cocktails that have …
approach for Ebola virus disease (EVD). However, all mAbs and mAb cocktails that have …
[HTML][HTML] Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses
Several ebolaviruses cause outbreaks of severe disease. Vaccines and monoclonal
antibody cocktails are available to treat Ebola virus (EBOV) infections, but not Sudan virus …
antibody cocktails are available to treat Ebola virus (EBOV) infections, but not Sudan virus …
[HTML][HTML] A two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates
Recent and ongoing outbreaks of Ebola virus disease (EVD) underscore the unpredictable
nature of ebolavirus reemergence and the urgent need for antiviral treatments …
nature of ebolavirus reemergence and the urgent need for antiviral treatments …