TRPM7, a divalent cation-selective channel with kinase domains, has been widely reported
to potentially affect cancers. In this study, we conducted multiple bioinformatic analyses …

Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical
extracellular and intracellular changes, translating them into cation influx to adapt and …

Cancer or endothelial cells preferably catabolize glucose through aerobic glycolysis rather
than oxidative phosphorylation. Intracellular ionic signaling has been shown to regulate …

Abstract Aims Sorafenib (Sora) represents one of the few effective drugs for the treatment of
advanced hepatocellular carcinoma (HCC), while resistance and cardiotoxicity limit its …

Reactive oxygen species (ROS) play an important role in regulating various physiological
functions by activating specific ion channels to mediate cell growth, proliferation …

Poor wound healing and pathological healing have been pressing issues in recent years, as
they impact human quality of life and pose risks of long-term complications. The study of …

Reprogramming of cancer metabolism has become increasingly concerned over the last
decade, particularly the reprogramming of glucose metabolism, also known as the" Warburg …

Objective Acute myeloid leukemia (AML) is an aggressive hematological malignancy with a
poor prognosis. This study aimed to investigate the action of PARP14 in the growth and …

Strengthened glycolysis is crucial for the macrophage pro-inflammatory response during
sepsis. Activating transcription factor 4 (ATF4) plays an important role in regulating glucose …

Ovarian cancer is the most lethal gynecologic tumor, with the highest mortality rate.
Numerous studies have been conducted on the treatment of ovarian cancer in the hopes of …