Vertebrates form a progressive series of up to three kidney organs during development—the
pronephros, mesonephros, and metanephros. Each kidney derives from the intermediate …

Prerequisite to any biological laboratory assay employing living animals is consideration
about its necessity, feasibility, ethics and the potential harm caused during an experiment …

Genetic disorders account for a wide range of renal diseases emerging during childhood
and adolescence. Due to the utilization of modern biochemical and biomedical techniques …

Because of essential role in homeostasis of the body fluid and excretion of wastes, kidney
damage can lead to severe impacts on health and survival of humans. For most chemicals …

The structural and functional similarity of the larval zebrafish pronephros to the human
nephron, together with the recent development of easier and more precise techniques to …

The zebrafish is a useful animal model to study the signaling pathways that orchestrate
kidney regeneration, as its renal nephrons are simple, yet they maintain the biological …

The human ubiquitous protein cystinosin is responsible for transporting the disulphide
amino acid cystine from the lysosomal compartment into the cytosol. In humans, Pathogenic …

The renal system is vital to maintain homeostasis in the body, where the kidneys contain
nephron functional units that remove metabolic waste from the bloodstream, regulate fluids …

Crude oil is known to induce developmental defects in teleost fish exposed during early life
stages (ELSs). While most studies in recent years have focused on cardiac endpoints …

The analysis of kidney malformation caused by environmental influences during
nephrogenesis or by hereditary nephropathies requires animal models allowing the in vivo …