Cholesterol and fatty acids grease the wheels of Mycobacterium tuberculosis pathogenesis

KM Wilburn, RA Fieweger… - Pathogens and …, 2018 - academic.oup.com
Tuberculosis is a distinctive disease in which the causative agent, Mycobacterium
tuberculosis, can persist in humans for decades by avoiding clearance from host immunity …

Mycolicibacterium cell factory for the production of steroid-based drug intermediates

A Zhao, X Zhang, Y Li, Z Wang, Y Lv, J Liu… - Biotechnology …, 2021 - Elsevier
Steroid-based drugs have been developed as the second largest medical category in
pharmaceutics. The well-established route of steroid industry includes two steps: the …

Pathogen roid rage: Cholesterol utilization by Mycobacterium tuberculosis

MF Wipperman, NS Sampson… - Critical reviews in …, 2014 - Taylor & Francis
The ability of science and medicine to control the pathogen Mycobacterium tuberculosis
(Mtb) requires an understanding of the complex host environment within which it resides …

Cholesterol-dependent transcriptome remodeling reveals new insight into the contribution of cholesterol to Mycobacterium tuberculosis pathogenesis

J Pawełczyk, A Brzostek, A Minias, P Płociński… - Scientific reports, 2021 - nature.com
Mycobacterium tuberculosis (Mtb) is an obligate human pathogen that can adapt to the
various nutrients available during its life cycle. However, in the nutritionally stringent …

Steroids as environmental compounds recalcitrant to degradation: genetic mechanisms of bacterial biodegradation pathways

ER Olivera, JM Luengo - Genes, 2019 - mdpi.com
Steroids are perhydro-1, 2-cyclopentanophenanthrene derivatives that are almost
exclusively synthesised by eukaryotic organisms. Since the start of the Anthropocene, the …

Comprehensive insights into transcriptional adaptation of intracellular mycobacteria by microbe-enriched dual RNA sequencing

RA Rienksma, M Suarez-Diez, HJ Mollenkopf… - BMC genomics, 2015 - Springer
Abstract Background The human pathogen Mycobacterium tuberculosis has the capacity to
escape eradication by professional phagocytes. During infection, M. tuberculosis resists the …

Revolutionizing control strategies against Mycobacterium tuberculosis infection through selected targeting of lipid metabolism

H Kim, SJ Shin - Cellular and Molecular Life Sciences, 2023 - Springer
Lipid species play a critical role in the growth and virulence expression of Mycobacterium
tuberculosis (Mtb), the causative agent of tuberculosis (TB). During Mtb infection, foamy …

Probing Perovskite Photocatalysis. Interfacial Electron Transfer between CsPbBr3 and Ferrocene Redox Couple

JT DuBose, PV Kamat - The Journal of Physical Chemistry Letters, 2019 - ACS Publications
Interfacial charge transfer between a semiconductor nanocrystal and a molecular relay is an
important step in nanomaterial photocatalysis. The ferrocene redox couple (Fc+/Fc0, E 0 …

Disturbed bovine mitochondrial lipid metabolism: a review

JH van der Kolk, JJ Gross, V Gerber… - Veterinary …, 2017 - Taylor & Francis
In mammals, excess energy is stored primarily as triglycerides, which are mobilized when
energy demands arise and cannot be covered by feed intake. This review mainly focuses on …

Latent tuberculosis: interaction of virulence factors in Mycobacterium tuberculosis

S Sundararajan, R Muniyan - Molecular Biology Reports, 2021 - Springer
Tuberculosis (TB) remains a prominent health concern worldwide. Besides extensive
research and vaccinations available, attempts to control the pandemic are cumbersome due …