Chronic Chagas heart disease management: from etiology to cardiomyopathy treatment

EA Bocchi, RB Bestetti, MI Scanavacca… - Journal of the American …, 2017 - jacc.org
Trypanosoma cruzi (T. cruzi) infection is endemic in Latin America and is becoming a
worldwide health burden. It may lead to heterogeneous phenotypes. Early diagnosis of T …

[HTML][HTML] Primary graft dysfunction after heart transplantation: a thorn amongst the roses

SSA Singh, JR Dalzell, C Berry, N Al-Attar - Heart Failure Reviews, 2019 - Springer
Primary graft dysfunction (PGD) remains the leading cause of early mortality post-heart
transplantation. Despite improvements in mechanical circulatory support and critical care …

Excessive O-GlcNAcylation Causes Heart Failure and Sudden Death

P Umapathi, OO Mesubi, PS Banerjee, N Abrol… - Circulation, 2021 - Am Heart Assoc
Background: Heart failure is a leading cause of death worldwide and is associated with the
rising prevalence of obesity, hypertension, and diabetes. O-GlcNAcylation (the attachment of …

Heart failure as a substrate and trigger for ventricular tachycardia

CK Alvarez, E Cronin, WL Baker, J Kluger - Journal of Interventional …, 2019 - Springer
Heart failure (HF) is a major cause of morbidity and mortality with more than 5.1 million
individuals affected in the USA. Ventricular tachyarrhythmias (VAs) including ventricular …

Predictors and clinical impact of late ventricular arrhythmias in patients with continuous-flow left ventricular assist devices

V Galand, E Flecher, V Auffret, S Boulé… - JACC: Clinical …, 2018 - jacc.org
Objectives: This study aimed to evaluate the incidence, clinical impact, and predictors of late
ventricular arrhythmias (VAs) in left ventricular assist device (LVAD) recipients aiming to …

Multidisciplinary Critical Care Management of Electrical Storm: JACC State-of-the-Art Review

JC Jentzer, PA Noseworthy, AH Kashou… - Journal of the American …, 2023 - jacc.org
Electrical storm (ES) reflects life-threatening cardiac electrical instability with 3 or more
ventricular arrhythmia episodes within 24 hours. Identification of underlying arrhythmogenic …

[HTML][HTML] Arrhythmogenic mechanisms in heart failure: linking β-adrenergic stimulation, stretch, and calcium

DM Johnson, G Antoons - Frontiers in physiology, 2018 - frontiersin.org
Heart failure (HF) is associated with elevated sympathetic tone and mechanical load. Both
systems activate signaling transduction pathways that increase cardiac output, but …

Antiarrhythmic drugs: risks and benefits

P Mankad, G Kalahasty - Medical Clinics, 2019 - medical.theclinics.com
The narrow therapeutic window of antiarrhythmic drugs (AADs) and their potential for lethal
proarrhythmia pose a unique clinical challenge without parallel in medical practice. 1 The …

Implantable cardioverter-defibrillators in patients with a continuous-flow left ventricular assist device: an analysis of the INTERMACS Registry

KJ Clerkin, VK Topkara, RT Demmer, JM Dizon… - JACC: Heart Failure, 2017 - jacc.org
Objectives: This study sought to determine if the presence of implantable cardioverter-
defibrillators (ICD) provided a mortality benefit during continuous-flow left ventricular assist …

Primary graft dysfunction after heart transplantation–unravelling the enigma

A Al-Adhami, SSA Singh, SD De, R Singh… - Current problems in …, 2022 - Elsevier
Primary graft dysfunction (PGD) remains the main cause of early mortality following heart
transplantation despite several advances in donor preservation techniques and therapeutic …