Early screening and diagnosis strategies of pancreatic cancer: a comprehensive review

J Yang, R Xu, C Wang, J Qiu, B Ren… - Cancer …, 2021 - Wiley Online Library
Pancreatic cancer is a highly malignant digestive system tumor with a poor prognosis. Most
pancreatic cancer patients are diagnosed at an advanced stage or even metastasis due to …

[HTML][HTML] Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes

A McGuigan, P Kelly, RC Turkington… - World journal of …, 2018 - ncbi.nlm.nih.gov
This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma
risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further …

The multicenter cancer of pancreas screening study: impact on stage and survival

M Dbouk, BW Katona, RE Brand, A Chak… - Journal of clinical …, 2022 - ascopubs.org
PURPOSE To report pancreas surveillance outcomes of high-risk individuals within the
multicenter Cancer of Pancreas Screening-5 (CAPS5) study and to update outcomes of …

Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma

Y Qian, Y Gong, Z Fan, G Luo, Q Huang… - Journal of hematology & …, 2020 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by a poor
prognosis and high mortality rate. Genetic mutations and altered molecular pathways serve …

Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) …

M Goggins, KA Overbeek, R Brand, S Syngal… - Gut, 2020 - gut.bmj.com
Background and aim The International Cancer of the Pancreas Screening Consortium met in
2018 to update its consensus recommendations for the management of individuals with …

Risk of neoplastic progression in individuals at high risk for pancreatic cancer undergoing long-term surveillance

MI Canto, JA Almario, RD Schulick, CJ Yeo, A Klein… - Gastroenterology, 2018 - Elsevier
Background & Aims Screening of individuals who have a high risk of pancreatic ductal
adenocarcinoma (PDAC), because of genetic factors, frequently leads to identification of …

Deleterious germline mutations in patients with apparently sporadic pancreatic adenocarcinoma

K Shindo, J Yu, M Suenaga… - Journal of Clinical …, 2017 - ascopubs.org
Purpose Deleterious germline mutations contribute to pancreatic cancer susceptibility and
are well documented in families in which multiple members have had pancreatic cancer …

Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia

AD Singhi, K McGrath, RE Brand, A Khalid, HJ Zeh… - Gut, 2018 - gut.bmj.com
Objective DNA-based testing of pancreatic cyst fluid (PCF) is a useful adjunct to the
evaluation of pancreatic cysts (PCs). Mutations in KRAS/GNAS are highly specific for …

Diagnosis and management of pancreatic cystic neoplasms: current evidence and guidelines

NCM Van Huijgevoort, M Del Chiaro… - Nature reviews …, 2019 - nature.com
Pancreatic cystic neoplasms (PCN) are a heterogeneous group of pancreatic cysts that
include intraductal papillary mucinous neoplasms, mucinous cystic neoplasms, serous cystic …

[HTML][HTML] Artificial intelligence and early detection of pancreatic cancer: 2020 summative review

B Kenner, ST Chari, D Kelsen, DS Klimstra, SJ Pandol… - Pancreas, 2021 - journals.lww.com
Despite considerable research efforts, pancreatic cancer is associated with a dire prognosis
and a 5-year survival rate of only 10%. Early symptoms of the disease are mostly …