Genome folding through loop extrusion by SMC complexes
IF Davidson, JM Peters - Nature reviews Molecular cell biology, 2021 - nature.com
Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …
serve important structural and regulatory roles. It has been proposed that these genomic …
The functions of BET proteins in gene transcription of biology and diseases
KL Cheung, C Kim, MM Zhou - Frontiers in molecular biosciences, 2021 - frontiersin.org
The BET (bromodomain and extra-terminal domain) family proteins, consisting of BRD2,
BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional …
BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional …
Chromatin structure dynamics during the mitosis-to-G1 phase transition
Features of higher-order chromatin organization—such as A/B compartments, topologically
associating domains and chromatin loops—are temporarily disrupted during mitosis …
associating domains and chromatin loops—are temporarily disrupted during mitosis …
Emerging evidence of chromosome folding by loop extrusion
Chromosome organization poses a remarkable physical problem with many biological
consequences: How can molecular interactions between proteins at the nanometer scale …
consequences: How can molecular interactions between proteins at the nanometer scale …
Synthetic lethal and resistance interactions with BET bromodomain inhibitors in triple-negative breast cancer
BET bromodomain inhibitors (BBDIs) are candidate therapeutic agents for triple-negative
breast cancer (TNBC) and other cancer types, but inherent and acquired resistance to BBDIs …
breast cancer (TNBC) and other cancer types, but inherent and acquired resistance to BBDIs …
[HTML][HTML] Cohesin-dependent and-independent mechanisms mediate chromosomal contacts between promoters and enhancers
MJ Thiecke, G Wutz, M Muhar, W Tang, S Bevan… - Cell reports, 2020 - cell.com
It is currently assumed that 3D chromosomal organization plays a central role in
transcriptional control. However, depletion of cohesin and CTCF affects the steady-state …
transcriptional control. However, depletion of cohesin and CTCF affects the steady-state …
Inhibitors of bromodomain and extra‐terminal proteins for treating multiple human diseases
E Kulikowski, BD Rakai… - Medicinal research …, 2021 - Wiley Online Library
Clinical development of bromodomain and extra‐terminal (BET) protein inhibitors differs
from the traditional course of drug development. These drugs are simultaneously being …
from the traditional course of drug development. These drugs are simultaneously being …
Inferring gene regulation from stochastic transcriptional variation across single cells at steady state
Regulatory relationships between transcription factors (TFs) and their target genes lie at the
heart of cellular identity and function; however, uncovering these relationships is often labor …
heart of cellular identity and function; however, uncovering these relationships is often labor …
LADL: light-activated dynamic looping for endogenous gene expression control
Mammalian genomes are folded into tens of thousands of long-range looping interactions.
The cause-and-effect relationship between looping and genome function is poorly …
The cause-and-effect relationship between looping and genome function is poorly …
BET proteins: Biological functions and therapeutic interventions
J Guo, Q Zheng, Y Peng - Pharmacology & Therapeutics, 2023 - Elsevier
Bromodomain and extra-terminal (BET) family member proteins (BRD2, BRD3, BRD4 and
BRDT) play a pivotal role in interpreting the epigenetic information of histone Kac …
BRDT) play a pivotal role in interpreting the epigenetic information of histone Kac …