A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …

P2X receptors are trimeric ATP-activated ion channels permeable to Na+, K+ and Ca2+. The
seven P2X receptor subtypes are implicated in physiological processes that include …

Cough is the most common reason for patients to visit a primary care physician, yet it
remains an unmet medical need. It can be idiopathic in nature but can also be a …

Pharmacological tool compounds are now available to define action at the adenosine (ARs),
P2Y and P2X receptors. We present a selection of the most commonly used agents to study …

Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …

This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

Purines have key roles in neurotransmission and neuromodulation, with their effects being
mediated by the purine and pyrimidine receptor subfamilies, P1, P2X and P2Y. Recently …

Men may not be able to multitask, but it is emerging that proteins can. This capacity of
proteins to exhibit more than one function is termed protein moonlighting, and, surprisingly …

The study of P2X receptors has long been handicapped by a poverty of small-molecule tools
that serve as selective agonists and antagonists. There has been progress, particularly in …