Because of its impact on multiple biological pathways, heparanase has emerged as a major
regulator of cancer, inflammation and other disease processes. Heparanase accomplishes …

In recent years, heparanase has attracted considerable attention as a promising target for
innovative pharmacological applications. Heparanase is a multifaceted protein endowed …

Exosomes are secreted vesicles of endosomal origin involved in signaling processes. We
recently showed that the syndecan heparan sulfate proteoglycans control the biogenesis of …

Emerging evidence indicates that exosomes play a key role in tumor-host cross-talk and that
exosome secretion, composition, and functional capacity are altered as tumors progress to …

Heparanase, the sole heparan sulfate (HS)-degrading endoglycosidase, regulates multiple
biological activities that enhance tumor growth, metastasis, angiogenesis, and inflammation …

Heparanase is the only enzyme in mammals capable of cleaving heparan sulfate, an activity
implicated in tumor inflammation, angiogenesis, and metastasis. Heparanase is secreted as …

Heparanase, the sole heparan sulfate degrading endoglycosidase, regulates multiple
biological activities that enhance tumor growth, angiogenesis and metastasis. Heparanase …

Heparanase activity is strongly implicated in structural remodeling of the extracellular matrix,
a process which can lead to invasion by tumor cells. In addition, heparanase augments …

Herpesviruses exemplified by herpes simplex virus-1 (HSV-1) attach to cell surface heparan
sulfate (HS) for entry into host cells. However, during a productive infection, the HS moieties …

Heparanase (HPSE) is an endoglycosidase that catalyses the cutting of the side chains of
heparan-sulphate proteoglycans (HS), thus determining the remodelling of the extracellular …