The MYH9 gene encodes the heavy chain of non-muscle myosin IIA, a widely expressed
cytoplasmic myosin that participates in a variety of processes requiring the generation of …

Non-muscle myosin II (NM II) is an actin-binding protein that has actin cross-linking and
contractile properties and is regulated by the phosphorylation of its light and heavy chains …

The small GTPase Rho is implicated in physiological functions associated with actin-myosin
filaments such as cytokinesis, cell motility, and smooth muscle contraction. We have recently …

Protein kinase C, an enzyme that is activated by the receptor-mediated hydrolysis of inositol
phospholipids, relays information in the form of a variety of extracellular signals across the …

Work performed with differentiated contractile smooth muscle tissue over the last two
decades has made clear that covalent modification of myosin by phosphorylation of the 20 …

Endothelial cell (EC) contraction results in intercellular gap formation and loss of the
selective vascular barrier to circulating macromolecules. We tested the hypothesis that …

Various extracellular informational signals such as those from a group of hormones and
some neurotransmitters appear to be passed from the cell surface into the cell interior by two …

Members of the nonmuscle myosin-2 (NM-2) family of actin-based molecular motors
catalyze the conversion of chemical energy into directed movement and force thereby acting …

Nonmuscle myosin II (NMII) is a multimeric protein complex that generates most mechanical
force in eukaryotic cells. NMII function is controlled at three main levels. The first level …

Ras and Rho proteins are GTP-regulated molecular switches that control multiple signaling
pathways in eukaryotic cells. Ras was among the first identified oncogenes, and it appears …