With the rising prevalence of autoimmune diseases, the role of the environment, specifically
the gut microbiota, in disease development has grown to be a major area of study. Recent …

Type 1 diabetes mellitus (T1D) can occur at any age, with a peak in incidence around
puberty. Classification between T1D and type 2 diabetes becomes more challenging with …

Genome-wide association studies (GWAS) have identified thousands of variants robustly
associated with complex traits. However, the biological mechanisms underlying these …

Abstract Type 1 diabetes (T1D) is an autoimmune disease in which immune cells destroy
insulin-producing beta cells. The aetiology of this complex disease is dependent on the …

Abstract Type 1 diabetes (T1D)—an autoimmune disease that destroys the pancreatic islets,
resulting in insulin deficiency—often begins early in life when islet autoantibody appearance …

Cytotoxic CD8 T lymphocytes play a central role in the tissue destruction of many
autoimmune disorders. In type 1 diabetes (T1D), insulin and its precursor preproinsulin are …

Autoimmune diabetes mellitus is a rare but significant side effect of treatment with immune
checkpoint inhibitors. Immune checkpoint inhibitor-induced diabetes mellitus (CPI-DM) is …

Abstract Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing
beta cells in the pancreas. Prevention of T1D will require the ability to detect and modulate …

Context: Little is known about the association between obesity and temporal trends in the
incidence of diabetes in children and young adults. Objective: We examined the recent …

Clinical research and practice in the 21st century is poised to be transformed by analysis of
computable electronic medical records and population-level genome-scale patient profiles …