Cells of the vascular wall are exquisitely sensitive to changes in their mechanical
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …

Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

Objective: To delineate temporal and spatial dynamics of vascular smooth muscle cell
(SMC) transcriptomic changes during aortic aneurysm development in Marfan syndrome …

Arterial occlusive disease is the leading cause of death in Western countries. Core
contemporary therapies for this disease include angioplasties, stents, endarterectomies and …

Objective The phenotypic plasticity of vascular smooth muscle cells (VSMCs) is central to
vessel growth and remodeling, but also contributes to cardiovascular pathologies. New …

Hypertension is both a cause and a consequence of central artery stiffening, which in turn is
an initiator and indicator of myriad disease conditions and thus all-cause mortality. Such …

BACKGROUND: Smooth muscle cell (SMC) phenotypic switching has been increasingly
detected in aortic aneurysm and dissection (AAD) tissues. However, the diverse SMC …

Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening condition associated
with Marfan syndrome (MFS), a disease caused by fibrillin-1 gene mutations. While various …

Aortic dissection is a critical cardiovascular disease due to the separation of media and
adventitia caused by the rupture of vascular wall intima. The disease has a high mortality …

Abstract Background and Aims Stanford type A aortic dissection (AD) is a degenerative
aortic remodelling disease marked by an exceedingly high mortality without effective …