Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

H Sies, DP Jones - Nature reviews Molecular cell biology, 2020 - nature.com
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

Physiological signaling functions of reactive oxygen species in stem cells: from flies to man

SA Sinenko, TY Starkova, AA Kuzmin… - Frontiers in cell and …, 2021 - frontiersin.org
Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …

[HTML][HTML] Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

H Sies - Redox biology, 2017 - Elsevier
Hydrogen peroxide emerged as major redox metabolite operative in redox sensing,
signaling and redox regulation. Generation, transport and capture of H 2 O 2 in biological …

Oxidative stress

H Sies, C Berndt, DP Jones - Annual review of biochemistry, 2017 - annualreviews.org
Oxidative stress is two sided: Whereas excessive oxidant challenge causes damage to
biomolecules, maintenance of a physiological level of oxidant challenge, termed oxidative …

[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

J Egea, I Fabregat, YM Frapart, P Ghezzi, A Görlach… - Redox biology, 2017 - Elsevier
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

ROS signaling and ER stress in cardiovascular disease

CD Ochoa, RF Wu, LS Terada - Molecular aspects of medicine, 2018 - Elsevier
The endoplasmic reticulum (ER) produces the vast majority of all proteins secreted into the
extracellular space, including hormones and cytokines, as well as cell surface receptors and …

An overview of the molecular mechanisms associated with myocardial ischemic injury: state of the art and translational perspectives

L Schirone, M Forte, L D'Ambrosio, V Valenti… - Cells, 2022 - mdpi.com
Cardiovascular disease is the leading cause of death in western countries. Among
cardiovascular diseases, myocardial infarction represents a life-threatening condition …

[HTML][HTML] Interactions of zinc-and redox-signaling pathways

C Hübner, H Haase - Redox biology, 2021 - Elsevier
Zinc and cellular oxidants such as reactive oxygen species (ROS) each participate in a
multitude of physiological functions. There is considerable overlap between the affected …

Biological production, detection, and fate of hydrogen peroxide

C WinterbournChristine - Antioxidants & redox signaling, 2018 - el.liebertpub.com
Abstract Significance: Hydrogen peroxide (H 2 O 2) is generated in numerous biological
processes. It transmits cellular signals, contributes to oxidative folding of exported proteins …

Regulation of redox signaling in HIF‐1‐dependent tumor angiogenesis

V Manuelli, C Pecorari, G Filomeni, E Zito - The FEBS journal, 2022 - Wiley Online Library
Angiogenesis is the process of blood vessel growth. The angiogenic switch consists of new
blood vessel formation that, in carcinogenesis, can lead to the transition from a harmless …