For many decades, Escherichia coli was the main model organism for the study of bacterial
membrane lipids. The results obtained served as a blueprint for membrane lipid …

The outer membrane of Gram-negative bacteria is essential for their survival in harsh
environments and provides intrinsic resistance to many antibiotics. This membrane is …

Oligomerization of membrane proteins in response to lipid binding has a critical role in many
cell-signalling pathways but is often difficult to define or predict. Here we report the …

Previous studies have established that the folding, structure and function of membrane
proteins are influenced by their lipid environments,,,,,, and that lipids can bind to specific …

The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, nonalcoholic
steatohepatitis (NASH), and cirrhosis. Recognition and timely diagnosis of these different …

Bacteria have evolved multiple strategies to sense and rapidly adapt to challenging and
ever-changing environmental conditions. The ability to alter membrane lipid composition, a …

Membrane lipid homeostasis is a vital facet of bacterial cell physiology. For decades,
research in bacterial lipid synthesis was largely confined to the Escherichia coli model …

Since it has been recognized that mitochondria are crucial not only for energy metabolism
but also for other cellular functions, there has been a growing interest in cardiolipin, the …

β-Barrel outer membrane proteins (OMPs) represent the major proteinaceous component of
the outer membrane (OM) of Gram-negative bacteria. These proteins perform key roles in …

The distribution of phospholipids across the inner membrane (IM) of Gram-negative bacteria
is unknown. We demonstrate that the IMs of Escherichia coli and Yersinia …