The dialogue between neuroinflammation and adult neurogenesis: mechanisms involved and alterations in neurological diseases
Adult neurogenesis occurs mainly in the subgranular zone of the hippocampal dentate gyrus
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …
[HTML][HTML] Shaping neuronal fate: functional heterogeneity of direct microglia-neuron interactions
The functional contribution of microglia to normal brain development, healthy brain function,
and neurological disorders is increasingly recognized. However, until recently, the nature of …
and neurological disorders is increasingly recognized. However, until recently, the nature of …
[HTML][HTML] Cell-to-cell communication by extracellular vesicles: focus on microglia
RC Paolicelli, G Bergamini, L Rajendran - Neuroscience, 2019 - Elsevier
Extracellular vesicles, including exosomes and microvesicles, are small, nano-to-micrometer
vesicles that are released from cells. While initially observed in immune cells and …
vesicles that are released from cells. While initially observed in immune cells and …
The effects of microglia‐and astrocyte‐derived factors on neurogenesis in health and disease
Hippocampal neurogenesis continues throughout life and has been suggested to play an
essential role in maintaining spatial cognitive function under physiological conditions. An …
essential role in maintaining spatial cognitive function under physiological conditions. An …
Microglia play an active role in obesity-associated cognitive decline
Obesity affects> 600 million people worldwide, a staggering number that appears to be on
the rise. One of the lesser known consequences of obesity is its deleterious effects on …
the rise. One of the lesser known consequences of obesity is its deleterious effects on …
Alzheimer's disease pathogenesis: Role of autophagy and mitophagy focusing in microglia
M Eshraghi, A Adlimoghaddam… - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is a debilitating neurological disorder, and currently, there is no
cure for it. Several pathologic alterations have been described in the brain of AD patients …
cure for it. Several pathologic alterations have been described in the brain of AD patients …
Targeting neuroinflammation to treat Alzheimer's disease
A Ardura-Fabregat, E Boddeke, A Boza-Serrano… - CNS drugs, 2017 - Springer
Over the past few decades, research on Alzheimer's disease (AD) has focused on
pathomechanisms linked to two of the major pathological hallmarks of extracellular …
pathomechanisms linked to two of the major pathological hallmarks of extracellular …
Microglia and aging: the role of the TREM2–DAP12 and CX3CL1-CX3CR1 axes
Depending on the species, microglial cells represent 5–20% of glial cells in the adult brain.
As the innate immune effector of the brain, microglia are involved in several functions …
As the innate immune effector of the brain, microglia are involved in several functions …
Tissue-specific role of CX3CR1 expressing immune cells and their relationships with human disease
M Lee, Y Lee, J Song, J Lee, SY Chang - Immune network, 2018 - synapse.koreamed.org
Abstract Chemokine (C-X3-C motif) ligand 1 (CX 3 CL1, also known as fractalkine) and its
receptor chemokine (C-X3-C motif) receptor 1 (CX 3 CR1) are widely expressed in immune …
receptor chemokine (C-X3-C motif) receptor 1 (CX 3 CR1) are widely expressed in immune …
Microglial control of neuronal development via somatic purinergic junctions
Microglia, the resident immune cells of the brain, play important roles during development.
Although bi-directional communication between microglia and neuronal progenitors or …
Although bi-directional communication between microglia and neuronal progenitors or …