The probabilistic model of Alzheimer disease: the amyloid hypothesis revised

GB Frisoni, D Altomare, DR Thal, F Ribaldi… - Nature Reviews …, 2022 - nature.com
The current conceptualization of Alzheimer disease (AD) is driven by the amyloid
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …

[HTML][HTML] Dementia prevention in memory clinics: recommendations from the European task force for brain health services

GB Frisoni, D Altomare, F Ribaldi, N Villain… - The Lancet Regional …, 2023 - thelancet.com
Observational population studies indicate that prevention of dementia and cognitive decline
is being accomplished, possibly as an unintended result of better vascular prevention and …

Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services—part 2 of 6

JM Ranson, T Rittman, S Hayat, C Brayne… - Alzheimer's Research & …, 2021 - Springer
We envisage the development of new Brain Health Services to achieve primary and
secondary dementia prevention. These services will complement existing memory clinics by …

[HTML][HTML] Identifying health conditions associated with Alzheimer's disease up to 15 years before diagnosis: an agnostic study of French and British health records

T Nedelec, B Couvy-Duchesne, F Monnet… - The Lancet Digital …, 2022 - thelancet.com
Background The identification of modifiable risk factors for Alzheimer's disease is paramount
for early prevention and the targeting of new interventions. We aimed to assess the …

Developing an explainable machine learning-based personalised dementia risk prediction model: a transfer learning approach with ensemble learning algorithms

SO Danso, Z Zeng, G Muniz-Terrera… - Frontiers in big Data, 2021 - frontiersin.org
Alzheimer's disease (AD) has its onset many decades before dementia develops, and work
is ongoing to characterise individuals at risk of decline on the basis of early detection …

Brain Health Services: organization, structure, and challenges for implementation. A user manual for Brain Health Services—part 1 of 6

D Altomare, JL Molinuevo, C Ritchie, F Ribaldi… - Alzheimer's research & …, 2021 - Springer
Dementia has a devastating impact on the quality of life of patients and families and comes
with a huge cost to society. Dementia prevention is considered a public health priority by the …

Clinical effect of early vs late amyloid positron emission tomography in memory clinic patients: the AMYPAD-DPMS randomized clinical trial

D Altomare, F Barkhof, C Caprioglio, LE Collij… - JAMA …, 2023 - jamanetwork.com
Importance Amyloid positron emission tomography (PET) allows the direct assessment of
amyloid deposition, one of the main hallmarks of Alzheimer disease. However, this …

Dementia risk communication. A user manual for Brain Health Services—part 3 of 6

LNC Visser, C Minguillon… - Alzheimer's Research & …, 2021 - Springer
Growing evidence suggests dementia incidence can be reduced through prevention
programs targeting risk factors. To accelerate the implementation of such prevention …

A multimodal precision-prevention approach combining lifestyle intervention with metformin repurposing to prevent cognitive impairment and disability: the MET …

M Barbera, J Lehtisalo, D Perera, M Aspö… - Alzheimer's Research & …, 2024 - Springer
Background Combining multimodal lifestyle interventions and disease-modifying drugs
(novel or repurposed) could provide novel precision approaches to prevent cognitive …

Dementia prevention and the GP's role: a qualitative interview study

D Jones, R Drewery, K Windle, S Humphrey… - British Journal of …, 2024 - bjgp.org
Background GPs play an increasingly important role in proactively preventing dementia.
Dementia in 40% of patients could be prevented or delayed by targeting 12 modifiable risk …