The probabilistic model of Alzheimer disease: the amyloid hypothesis revised
The current conceptualization of Alzheimer disease (AD) is driven by the amyloid
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …
[HTML][HTML] Dementia prevention in memory clinics: recommendations from the European task force for brain health services
Observational population studies indicate that prevention of dementia and cognitive decline
is being accomplished, possibly as an unintended result of better vascular prevention and …
is being accomplished, possibly as an unintended result of better vascular prevention and …
Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services—part 2 of 6
We envisage the development of new Brain Health Services to achieve primary and
secondary dementia prevention. These services will complement existing memory clinics by …
secondary dementia prevention. These services will complement existing memory clinics by …
[HTML][HTML] Identifying health conditions associated with Alzheimer's disease up to 15 years before diagnosis: an agnostic study of French and British health records
T Nedelec, B Couvy-Duchesne, F Monnet… - The Lancet Digital …, 2022 - thelancet.com
Background The identification of modifiable risk factors for Alzheimer's disease is paramount
for early prevention and the targeting of new interventions. We aimed to assess the …
for early prevention and the targeting of new interventions. We aimed to assess the …
Developing an explainable machine learning-based personalised dementia risk prediction model: a transfer learning approach with ensemble learning algorithms
SO Danso, Z Zeng, G Muniz-Terrera… - Frontiers in big Data, 2021 - frontiersin.org
Alzheimer's disease (AD) has its onset many decades before dementia develops, and work
is ongoing to characterise individuals at risk of decline on the basis of early detection …
is ongoing to characterise individuals at risk of decline on the basis of early detection …
Brain Health Services: organization, structure, and challenges for implementation. A user manual for Brain Health Services—part 1 of 6
Dementia has a devastating impact on the quality of life of patients and families and comes
with a huge cost to society. Dementia prevention is considered a public health priority by the …
with a huge cost to society. Dementia prevention is considered a public health priority by the …
Clinical effect of early vs late amyloid positron emission tomography in memory clinic patients: the AMYPAD-DPMS randomized clinical trial
Importance Amyloid positron emission tomography (PET) allows the direct assessment of
amyloid deposition, one of the main hallmarks of Alzheimer disease. However, this …
amyloid deposition, one of the main hallmarks of Alzheimer disease. However, this …
Dementia risk communication. A user manual for Brain Health Services—part 3 of 6
LNC Visser, C Minguillon… - Alzheimer's Research & …, 2021 - Springer
Growing evidence suggests dementia incidence can be reduced through prevention
programs targeting risk factors. To accelerate the implementation of such prevention …
programs targeting risk factors. To accelerate the implementation of such prevention …
A multimodal precision-prevention approach combining lifestyle intervention with metformin repurposing to prevent cognitive impairment and disability: the MET …
M Barbera, J Lehtisalo, D Perera, M Aspö… - Alzheimer's Research & …, 2024 - Springer
Background Combining multimodal lifestyle interventions and disease-modifying drugs
(novel or repurposed) could provide novel precision approaches to prevent cognitive …
(novel or repurposed) could provide novel precision approaches to prevent cognitive …
Dementia prevention and the GP's role: a qualitative interview study
D Jones, R Drewery, K Windle, S Humphrey… - British Journal of …, 2024 - bjgp.org
Background GPs play an increasingly important role in proactively preventing dementia.
Dementia in 40% of patients could be prevented or delayed by targeting 12 modifiable risk …
Dementia in 40% of patients could be prevented or delayed by targeting 12 modifiable risk …