Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms.
In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne …

Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

Background Sequencing the genomes of multiple, taxonomically diverse eukaryotes
enables in-depth comparative-genomic analysis which is expected to help in reconstructing …

Although the U3 small nucleolar RNA (snoRNA), a member of the box C/D class of
snoRNAs, was identified with the spliceosomal small nuclear RNAs (snRNAs) over 30 years …

Ribosome synthesis is a highly complex and coordinated process that occurs not only in the
nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells. Based on the …

The coordinated integration of ribosomal RNA and protein into two functional ribosomal
subunits is safeguarded by quality control checkpoints that ensure ribosomes are correctly …

The pathway and complete collection of factors that orchestrate ribosome assembly are not
clear. To address these problems, we affinity purified yeast preribosomal particles …

The targets of in vivo studies of the ribosomal assembly process are mainly the events of
rRNA processing, whereas in vitro studies (total reconstitution) focus on principls of the …

The synthesis of ribosomes in eukaryotes involves processing of pre-ribosomal RNA (pre-
rRNA) and sequential assembly of a large number of ribosomal proteins on the rRNAs …

Proper regulation of ribosome biosynthesis is mandatory for cellular adaptation, growth and
proliferation. Ribosome biogenesis is the most energetically demanding cellular process …