It is fifty years since the first chemical synthesis of a dinucleoside phosphate and a
dinucleotide with natural 3′→ 5′-internucleotide linkages was reported. The main …

Historically, the discovery of the helical structure of DNA by Watson and Crick1 provided the
impetus to attempt the challenging synthesis of oligonucleotides of defined sequences …

Anuschirwan Peyman was born on October 19, 1958, in Freiburg i. Br., FRG He attended
Albert-Ludwigs Universitat Freiburg from 1977 to 1983, where he received his Diplom in …

In October 1953, I began my research career as a Ph. D. student in the laboratory of
Alexander Todd (who became Sir Alexander Todd in 1954 and then Lord Todd of …

Abstract Two model compounds, 1 and 2, have been studied to test the stability of the t-
butyldimethylsilyl (t-BDMSi) group towards conditions used during chemical synthesis of …

Efficient solid-phase synthesis of a series of oligoribonucleotides of up to 20 residues is
described that utilises the 9-fluorenylmethoxycarbonyl group (Fmoc) for 5′-protection and 4 …

A biopolymer is synthesized by assembling monomeric or oligomeric blocks. Each block
features at least a nucleophilic and an electrophilic function, ie, the α-amino and the …

The internucleotide linkage of uridylyl-(3′→ 5′)-uridine (r [UpU]) does not undergo
detectable hydrolytic cleavage or migration in ca. 24 hr in 0.01 mol dm-3 hydrochloric acid …

An approach to the solid-phase synthesis of oligo-and poly-ribonucleotides is described.
The synthetic strategy involves the use of building blocks in which two acid-labile groups, 1 …

A number of different protecting groups were compared with respect to their usefulness for
protection of 2′-hydroxyl functions during synthesis of oligoribonucleotides using the H …