Exosomes based strategies for brain drug delivery

FU Rehman, Y Liu, M Zheng, B Shi - Biomaterials, 2023 - Elsevier
Exosome application has emerged as a promising nanotechnology discipline for various
diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug …

The landscape of biomimetic nanovesicles in brain diseases

Q You, F Liang, G Wu, F Cao, J Liu, Z He… - Advanced …, 2024 - Wiley Online Library
Brain diseases, such as brain tumors, neurodegenerative diseases, cerebrovascular
diseases, and brain injuries, are caused by various pathophysiological changes, which pose …

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

JA Welsh, DCI Goberdhan, L O'Driscoll… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

[HTML][HTML] Engineered EVs designed to target diseases of the CNS

L Nieland, S Mahjoum, E Grandell, K Breyne… - Journal of Controlled …, 2023 - Elsevier
Diseases of the central nervous system (CNS) are challenging to treat, mainly due to the
blood-brain barrier (BBB), which restricts drugs in circulation from entering target regions in …

Fluorescent, phosphorescent, magnetic resonance contrast and radioactive tracer labelling of extracellular vesicles

K Wardhani, A Levina, GER Grau, PA Lay - Chemical Society Reviews, 2024 - pubs.rsc.org
This review focusses on the significance of fluorescent, phosphorescent labelling and
tracking of extracellular vesicles (EVs) for unravelling their biology, pathophysiology, and …

[HTML][HTML] Synaptic proteins in neuron-derived extracellular vesicles as biomarkers for Alzheimer's disease: novel methodology and clinical proof of concept

E Eitan, T Thornton-Wells, K Elgart… - Extracellular vesicles …, 2023 - ncbi.nlm.nih.gov
Aims: Blood biomarkers can improve drug development for Alzheimer's disease (AD) and its
treatment. Neuron-derived extracellular vesicles (NDEVs) in plasma offer a minimally …

[HTML][HTML] Exogenous loading of extracellular vesicles, virus-like particles, and lentiviral vectors with supercharged proteins

K Breyne, S Ughetto, D Rufino-Ramos… - Communications …, 2022 - nature.com
Cell membrane-based biovesicles (BVs) are important candidate drug delivery vehicles and
comprise extracellular vesicles, virus-like particles, and lentiviral vectors. Here, we introduce …

[HTML][HTML] Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases

SAM Sherazi, A Abbasi, A Jamil, M Uzair… - Neural Regeneration …, 2023 - journals.lww.com
Aging is linked to the deterioration of many physical and cognitive abilities and is the leading
risk factor for Alzheimer's disease. The growing aging population is a significant healthcare …

[HTML][HTML] Genetically engineered extracellular vesicles harboring transmembrane scaffolds exhibit differences in their size, expression levels of specific surface markers …

J Zhang, A Brown, B Johnson, D Diebold, K Asano… - Pharmaceutics, 2022 - mdpi.com
Background: Human cell-secreted extracellular vesicles (EVs) are versatile nanomaterials
suitable for disease-targeted drug delivery and therapy. Native EVs, however, usually do not …

[HTML][HTML] Extracellular communication between brain cells through functional transfer of Cre mRNA mediated by extracellular vesicles

D Rufino-Ramos, K Leandro, PRL Perdigão, K O'Brien… - Molecular Therapy, 2023 - cell.com
In the central nervous system (CNS), the crosstalk between neural cells is mediated by
extracellular mechanisms, including brain-derived extracellular vesicles (bdEVs). To study …