Pharmacological activity and mechanism of tanshinone IIA in related diseases

R Guo, L Li, J Su, S Li, SE Duncan, Z Liu… - Drug Design …, 2020 - Taylor & Francis
Salvia miltiorrhiza:(Danshen) is a significant (traditional Chinese medication) natural
remedy, enhancing blood circulation and clear blood stasis. In this view, it is widely used …

Prospective therapeutic potential of Tanshinone IIA: An updated overview

MA Ansari, FB Khan, HA Safdari, A Almatroudi… - Pharmacological …, 2021 - Elsevier
In the past decades, the branch of complementary and alternative medicine based
therapeutics has gained considerable attention worldwide. Pharmacological efficacy of …

Exploring the mechanisms underlying the therapeutic effect of Salvia miltiorrhiza in diabetic nephropathy using network pharmacology and molecular docking

L Zhang, L Han, X Wang, Y Wei, J Zheng… - Bioscience …, 2021 - portlandpress.com
The mechanisms underlying the therapeutic effect of Salvia miltiorrhiza (SM) on diabetic
nephropathy (DN) were examined using a systematic network pharmacology approach and …

Pharmacological properties of tanshinones, the natural products from Salvia miltiorrhiza

X Wang, Y Yang, X Liu, X Gao - Advances in pharmacology, 2020 - Elsevier
Abstract Danshen (Cai, et al. 2016) is the dry root and rhizome of the herbaceous plant
Salvia miltiorrhiza Bge. of family labiatae, a perennial plant that is native to China and …

New insights into the effects of individual Chinese herbal medicines on chronic kidney disease

M Shao, C Ye, G Bayliss, S Zhuang - Frontiers in pharmacology, 2021 - frontiersin.org
The clinical and experimental study into the effects of Chinese herbal medicines on chronic
kidney disease has evolved over the past 40 years with new insight into their mechanism …

Pharmacological potential of the combination of Salvia miltiorrhiza (Danshen) and Carthamus tinctorius (Honghua) for diabetes mellitus and its cardiovascular …

JO Orgah, S He, Y Wang, M Jiang, Y Wang… - Pharmacological …, 2020 - Elsevier
Metabolic syndrome, such as diabetes mellitus, obesity, atherosclerosis, and high blood
pressure (HBP), are closely linked pathophysiologically. However, current monotherapies …

Oridonin protects against the inflammatory response in diabetic nephropathy by inhibiting the TLR4/p38-MAPK and TLR4/NF-κB signaling pathways

J Li, L Bao, D Zha, L Zhang, P Gao, J Zhang… - International …, 2018 - Elsevier
Inflammation plays a pivotal role in the development and progression of diabetic
nephropathy (DN). Oridonin (Ori), a component isolated from Rabdosia rubescens …

IL-6 receptor blockade ameliorates diabetic nephropathy via inhibiting inflammasome in mice

R Wu, X Liu, J Yin, H Wu, X Cai, N Wang, Y Qian… - Metabolism, 2018 - Elsevier
Abstract Background and Objective Interleukin 6 (IL-6) has been identified as a key mediator
in inflammation, immune responses and glucose metabolism. In this study, we assessed the …

Luteolin attenuates diabetic nephropathy through suppressing inflammatory response and oxidative stress by inhibiting STAT3 pathway

M Zhang, L He, J Liu, L Zhou - Experimental and Clinical …, 2021 - thieme-connect.com
Background Diabetic nephropathy (DN) is the leading cause of end-stage renal disease
(ESRD). DN has many pathological changes, but tubular injury is considered to be a crucial …

[HTML][HTML] Tanshinone IIA protects intestinal epithelial cells from deoxynivalenol-induced pyroptosis

C Zhang, F Chen, Y Wang, K Zhang, X Yang… - … and Environmental Safety, 2024 - Elsevier
Deoxynivalenol (DON) is the most common mycotoxin in food and feed, which can cause
undesirable effects, including diarrhea, emesis, weight loss, and growth delay in livestock …