Redox processes are at the heart of synthetic methods that rely on either electrochemistry or
photoredox catalysis, but how do electrochemistry and photoredox catalysis compare? Both …

Skeletal editing involves making specific point‐changes to the core of a molecule through
the selective insertion, deletion or exchange of atoms. It thus represents a potentially …

The “magic methyl” effect, a dramatic boost in the potency of biologically active compounds
from the incorporation of a single methyl group, provides a simple yet powerful strategy …

This chapter provides a short overview of the history of morphine since it's isolation by
Sertürner in 1805. The biosynthesis of the title alkaloid as well as all total and formal …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Employment of a combination of an organophotoredox catalyst with Wilkinson's catalyst (Rh
(PPh3) 3Cl) has given rise to an unprecedented method for hydrogen-isotope exchange …

N-dealkylation, the removal of an N-alkyl group from an amine, is an important chemical
transformation which provides routes for the synthesis of a wide range of pharmaceuticals …

In the present paper, for the first time, a planar electrochemical cell formed of a novel screen-
printed sensor with the working boron-doped diamond electrode (BDDE) was used for the …

Electrochemical strategies have been a powerful approach for the synthesis of valuable
intermediates, in particular heterocyclic motifs. Because of the mild nature, a wide range of …

Noroxymorphone is a pivotal intermediate in the synthesis of important opioid antagonists
such as naloxone and naltrexone. The preparation of noroxymorphone from thebaine, a …