Alcohol use disorders (AUD) are commonly occurring, heritable and polygenic disorders
with etiological origins in the brain and the environment. To outline the causes and …

Abstract Alcohol Use Disorder is a complex genetic disorder, involving genetic, neural, and
environmental factors, and their interactions. The Collaborative Study on the Genetics of …

To understand the genetics of steroid-sensitive nephrotic syndrome (SSNS), we conducted a
genome-wide association study in 987 childhood SSNS patients and 3,206 healthy controls …

Genome-wide association studies (GWAS) in admixed populations such as African
Americans (AA) have limited sample sizes, resulting in poor performance of polygenic risk …

Abstract Fibroblast growth factor 21 (FGF21) is a liver‐derived hormone with pleiotropic
beneficial effects on metabolism. Paradoxically, FGF21 levels are elevated in metabolic …

Genetic mechanisms of alternative mRNA splicing have been shown in the brain for a
variety of neuropsychiatric traits, but not substance use disorders. Our study utilized RNA …

How the genetic composition of a population changes through stochastic processes, such as
genetic drift, in combination with deterministic processes, such as selection, is critical to …

Allele-specific expression (ASE) analysis detects the relative abundance of alleles at
heterozygous loci as a proxy for cis-regulatory variation, which affects the personal …

Background Long noncoding RNA (lncRNA) have been implicated in the etiology of alcohol
use. Since lncRNA provide another layer of complexity to the transcriptome, assessing their …

MiRNAs regulate the expression of hepatic genes involved in pharmacokinetics and
pharmacodynamics. Genetic variants affecting miRNA binding (mirSNPs) have been …