Helminth parasite infections are associated with a battery of immunomodulatory
mechanisms that affect all facets of the host immune response to ensure their persistence …

Helminth parasites infect almost one-third of the world's population, primarily in tropical
regions. However, regions where helminth parasites are endemic record much lower …

The vertebrate immune system has evolved in concert with a broad range of infectious
agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth …

According to the 'hygiene hypothesis', the decreasing incidence of infections in western
countries and more recently in developing countries is at the origin of the increasing …

Schistosomiasis is a major cause of morbidity in humans invoked by chronic infection with
parasitic trematodes of the genus Schistosoma. Schistosomes have a complex life-cycle …

Foxp3-expressing regulatory T (T reg) cells have been implicated in parasite-driven
inhibition of host immunity during chronic infection. We addressed whether parasites can …

The development of type 1 diabetes involves a complex interaction between pancreatic β-
cells and cells of both the innate and adaptive immune systems. Analyses of the interactions …

Helminth infections are ubiquitous worldwide and can trigger potent immune responses that
differ from and potentially antagonize host protective responses to microbial pathogens. In …

Epidemiological and interventional human studies, as well as experiments in animal
models, strongly indicate that helminth parasitic infections can confer protection from …

There is increasing interest in helminth parasite modulation of the immune system, both from
the fundamental perspective of the “arms race” between host and parasite, and equally …