Mid-trimester preterm premature rupture of membranes (PPROM), defined as rupture of fetal
membranes prior to 28 weeks of gestation, complicates approximately 0.4%–0.7% of all …

Evidence from family and twin-based studies provide strong support for a significant
contribution of maternal and fetal genetics to the timing of parturition and spontaneous …

The transcriptional factor NF-κB is a nuclear factor involved in both physiological and
pathological processes. This factor can control the transcription of more than 400 genes …

Rupture of the fetal membranes (FM) is precipitated by stretch forces acting upon
biochemically mediated, pre-weakened tissue. Term FM develop a para-cervical weak zone …

Exosomes are membrane-bound nanovesicles that transport molecular signals between
cells. This study determined changes in maternal plasma exosome proteomics contents in …

Spontaneous preterm birth (PTB) is a major obstetrical problem around the globe and the
mechanisms leading to PTB are unclear. Recently, changes in the circulating levels of …

Preterm birth (PTB) complications are the leading cause of long-term morbidity and mortality
in children. By using whole blood samples, we integrated whole-genome sequencing …

Objective To assess the association between vaginal microbiome (VMB) composition and
recurrent early spontaneous preterm birth (sPTB)/preterm prelabour rupture of membranes …

Preterm birth contributes significantly to neonatal mortality and morbidity. Despite its global
significance, there has only been limited progress in preventing preterm birth. Spontaneous …

Background Twin studies have revealed a significant contribution of the fetal genome to risk
of preterm birth. Preterm premature rupture of membranes (PPROM) is the leading …