G protein-coupled receptors (GPCRs) are targets for∼ 35% of approved drugs but only∼
15% of the∼ 800 human GPCRs are currently such targets. GPCRomics, the use of …

Primary aldosteronism is the most common form of secondary hypertension with a
prevalence of 5–10% in hypertensive patients. Aldosterone-producing adenoma (APA) is a …

Purpose It is challenging to differentiate unilateral aldosterone-producing adenoma (APA)
from bilateral idiopathic adrenal hyperplasia (IAH) and nonfunctional adrenal adenoma …

Context Aldosterone biosynthesis is regulated principally by ACTH and gene mutations as
well as by angiotensin II and serum potassium. In addition, previous studies have reported …

The endoplasmic reticulum (ER) plays a pivotal role in syntheses of proteins and steroid
hormones and regulation of intracellular Ca2+ level. We aimed to investigate ER-associated …

This review reports the main molecular alterations leading to development of benign cortisol-
and/or aldosterone-secreting adrenal tumors. Causes of adrenal Cushing syndrome can be …

Fluorene-9-bisphenol (BHPF) is an emerging contaminant. Presently, there is no report on
its interaction with G protein-coupled estrogen receptor 1 (GPER). By using an integrated …

We aimed to investigate the diagnostic and prognostic value of 68Ga-pentixafor PET/CT
imaging in noncancer patients with suspected adrenal masses. Methods: Sixty-four patients …

Primary aldosteronism (PA) is the most common cause of secondary hypertension. It
predisposes to adverse outcomes such as nephrotoxicity and cardiovascular damage, which …

Aldosterone secretion by the zona glomerulosa of the adrenal cortex is controlled by
circulating factors including the renin angiotensin system (RAS) and potassium …