Background and Purpose—The purpose of these guidelines is to provide an up-to-date
comprehensive set of recommendations in a single document for clinicians caring for adult …

Epidemiological evidence suggests that the incidence of ischaemic stroke in young adults
(18–50 years) has increased substantially. These patients have a long life expectancy after …

Background Under current guidelines, intravenous thrombolysis is used to treat acute stroke
only if it can be ascertained that the time since the onset of symptoms was less than 4.5 …

Background Trials of patent foramen ovale (PFO) closure to prevent recurrent stroke have
been inconclusive. We investigated whether patients with cryptogenic stroke and …

Background The efficacy of closure of a patent foramen ovale (PFO) in the prevention of
recurrent stroke after cryptogenic stroke is uncertain. We investigated the effect of PFO …

The optimal blood pressure (BP) management in acute ischaemic stroke (AIS) and acute
intracerebral haemorrhage (ICH) remains controversial. These European Stroke …

The presence of a patent foramen ovale (PFO) is implicated in the pathogenesis of a number
of medical conditions; however, the subject remains controversial and no official statements …

Background High systolic blood pressure after successful endovascular therapy for acute
ischaemic stroke is associated with increased risk of intraparenchymal haemorrhage …

Importance Mechanical thrombectomy using a stent retriever or contact aspiration is widely
used for treatment of patients with acute ischemic stroke due to anterior circulation large …

Background Tenecteplase is a newer thrombolytic agent with some pharmacological
advantages over alteplase. Previous phase 2 trials of tenecteplase in acute ischaemic stroke …