Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Post-translational modifications of histones regulate all DNA-templated processes, including
replication, transcription and repair. These modifications function as platforms for the …

Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Cells undergoing developmental processes are characterized by persistent non-genetic
alterations in chromatin, termed epigenetic changes, represented by distinct patterns of DNA …

Alterations of chromatin structure have been shown to be crucial for response to cell
signaling and for programmed gene expression in development. Posttranslational histone …

Lysine acetylation of histones defines the epigenetic status of human embryonic stem cells
and orchestrates DNA replication, chromosome condensation, transcription, telomeric …

Designer amino acids, beyond the canonical 20 that are normally used by cells, can now be
site-specifically encoded into proteins in cells and organisms. This is achieved …

Changes to the chromatin structure accompany aging, but the molecular mechanisms
underlying aging and the accompanying changes to the chromatin are unclear. Here, we …

1Department of Medicine; and 2Cancer Biology Program; Stanford University School of
Medicine; Stanford, CA USA; 3Geriatric Research, Education and Clinical Center; VA Palo …

The genus Trichoderma contains fungi with high relevance for humans, with applications in
enzyme production for plant cell wall degradation and use in biocontrol. Here, we provide a …