Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

Regulated fibroblast growth factor (FGF) signalling is a prerequisite for the correct
development and homeostasis of articular cartilage, as evidenced by the fact that aberrant …

Mechanical injury is the most important risk factor in osteoarthritis (OA) development.
Although once considered a passive disease of mechanical attrition, injury drives active …

Articular cartilage functions to transmit and translate loads. In a classical structure–function
relationship, the tissue resides in a dynamic mechanical environment that drives the …

MicroRNAs have been shown to function in cartilage development and homeostasis, as well
as in progression of osteoarthritis. The objective of the current study was to identify …

Osteoarthritis is characterized by the loss of the articular cartilage, bone remodeling, pain,
and disability. No pharmacological intervention can currently halt progression of …

Objective The role of inflammation in structural and symptomatic osteoarthritis (OA) remains
unclear. One key mediator of inflammation is the chemokine CCL2, primarily responsible for …

Mechanical loading is essential for chondrocyte health. Chondrocytes can sense and
respond to various extracellular mechanical signals through an integrated set of …

Objectives One mechanism by which cartilage responds to mechanical load is by releasing
heparin-bound growth factors from the pericellular matrix (PCM). By proteomic analysis of …

Objective Surgical knee joint distraction (KJD) leads to clinical improvement in knee
osteoarthritis (OA) and also apparent cartilage regeneration by magnetic resonance …