Radiomics and its emerging role in lung cancer research, imaging biomarkers and clinical management: State of the art

G Lee, HY Lee, H Park, ML Schiebler… - European journal of …, 2017 - Elsevier
With the development of functional imaging modalities we now have the ability to study the
microenvironment of lung cancer and its genomic instability. Radiomics is defined as the use …

Targeted therapy and immunotherapy in the treatment of non–small cell lung cancer

GS Shroff, PM de Groot… - Radiologic …, 2018 - radiologic.theclinics.com
The treatment strategy in advanced non–small cell lung cancer (NSCLC) has evolved from
the use of empirical chemotherapy to a more personalized approach based on histology and …

Somatic mutations drive distinct imaging phenotypes in lung cancer

E Rios Velazquez, C Parmar, Y Liu, TP Coroller… - Cancer research, 2017 - AACR
Tumors are characterized by somatic mutations that drive biological processes ultimately
reflected in tumor phenotype. With regard to radiographic phenotypes, generally …

A clinical-radiomics nomogram for the preoperative prediction of lung metastasis in colorectal cancer patients with indeterminate pulmonary nodules

TD Hu, SP Wang, L Huang, JZ Wang, DB Shi, Y Li… - European …, 2019 - Springer
Objectives To develop and validate a clinical-radiomics nomogram for preoperative
prediction of lung metastasis for colorectal cancer (CRC) patients with indeterminate …

[HTML][HTML] Multi-channel multi-task deep learning for predicting EGFR and KRAS mutations of non-small cell lung cancer on CT images

Y Dong, L Hou, W Yang, J Han, J Wang… - … imaging in medicine …, 2021 - ncbi.nlm.nih.gov
Background Predicting the mutation statuses of 2 essential pathogenic genes [epidermal
growth factor receptor (EGFR) and Kirsten rat sarcoma (KRAS)] in non-small cell lung cancer …

[HTML][HTML] Non-invasive tumor genotyping using radiogenomic biomarkers, a systematic review and oncology-wide pathway analysis

RW Jansen, P van Amstel, RM Martens, IE Kooi… - Oncotarget, 2018 - ncbi.nlm.nih.gov
With targeted treatments playing an increasing role in oncology, the need arises for fast non-
invasive genotyping in clinical practice. Radiogenomics is a rapidly evolving field of …

Imaging Features and Metastatic Patterns of Advanced ALK-Rearranged Non–Small Cell Lung Cancer

DP Mendoza, JJ Lin, MM Rooney… - American Journal of …, 2020 - Am Roentgen Ray Soc
OBJECTIVE. ALK rearrangements are an established targetable oncogenic driver in non–
small cell lung cancer (NSCLC). The goal of this study was to determine the imaging …

Computed tomography imaging features and distribution of metastases in ROS1-rearranged non–small-cell lung cancer

SR Digumarthy, DP Mendoza, JJ Lin, T Chen… - Clinical Lung Cancer, 2020 - Elsevier
Background ROS proto-oncogene 1 (ROS1) rearrangements are a known molecular target
in non–small-cell lung cancer (NSCLC). Our goal was to determine whether ROS1 …

Computed tomography imaging characteristics of non–small-cell lung cancer with anaplastic lymphoma kinase rearrangements: a systematic review and meta …

DP Mendoza, J Stowell, A Muzikansky, JAO Shepard… - Clinical Lung Cancer, 2019 - Elsevier
Introduction Several studies have suggested that non–small-cell lung cancer (NSCLC)
patients who harbor anaplastic lymphoma kinase (ALK) rearrangement might have different …

[HTML][HTML] Clinical and CT patterns to predict EGFR mutation in patients with non-small cell lung cancer: A systematic literature review and meta-analysis

AFH Ortiz, TC Camacho, AF Vásquez… - European Journal of …, 2022 - Elsevier
Purpose This study aims to determine if the presence of specific clinical and computed
tomography (CT) patterns are associated with epidermal growth factor receptor (EGFR) …