Revisiting the critical roles of reactive astrocytes in neurodegeneration
K Qian, X Jiang, ZQ Liu, J Zhang, P Fu, Y Su… - Molecular …, 2023 - nature.com
Astrocytes, an integral component of the central nervous system (CNS), contribute to the
maintenance of physiological homeostasis through their roles in synaptic function, K+ …
maintenance of physiological homeostasis through their roles in synaptic function, K+ …
Astrocytes: dissecting their diverse roles in amyotrophic lateral sclerosis and frontotemporal dementia
CF Valori, C Sulmona, L Brambilla, D Rossi - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal
neurodegenerative disorders often co-occurring in the same patient, a feature that suggests …
neurodegenerative disorders often co-occurring in the same patient, a feature that suggests …
Emerging role of miR-21-5p in neuron–glia dysregulation and exosome transfer using multiple models of Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder associated with neuron–glia
dysfunction and dysregulated miRNAs. We previously reported upregulated miR-124/miR …
dysfunction and dysregulated miRNAs. We previously reported upregulated miR-124/miR …
Remodeling of astrocyte secretome in amyotrophic lateral sclerosis: uncovering novel targets to combat astrocyte-mediated toxicity
W Ng, SY Ng - Translational neurodegeneration, 2022 - Springer
Amyotrophic lateral sclerosis (ALS) is an adult-onset paralytic disease characterized by
progressive degeneration of upper and lower motor neurons in the motor cortex, brainstem …
progressive degeneration of upper and lower motor neurons in the motor cortex, brainstem …
Why should we care about astrocytes in a motor neuron disease?
K Stoklund Dittlau, L Van Den Bosch - Frontiers in Molecular …, 2023 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in adults,
causing progressive degeneration of motor neurons, which results in muscle atrophy …
causing progressive degeneration of motor neurons, which results in muscle atrophy …
Smart Nanoscale Extracellular Vesicles in the Brain: Unveiling their Biology, Diagnostic Potential, and Therapeutic Applications
Information exchange is essential for the brain, where it communicates the physiological and
pathological signals to the periphery and vice versa. Extracellular vesicles (EVs) are a …
pathological signals to the periphery and vice versa. Extracellular vesicles (EVs) are a …
Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43 A90V mutation display a mild reactive state and release polyP toxic to motoneurons
F Rojas, R Aguilar, S Almeida, E Fritz… - Frontiers in Cell and …, 2023 - frontiersin.org
Astrocytes play a critical role in the maintenance of a healthy central nervous system and
astrocyte dysfunction has been implicated in various neurodegenerative disorders, including …
astrocyte dysfunction has been implicated in various neurodegenerative disorders, including …
Astrocytes: The Stars in Neurodegeneration?
K Stoklund Dittlau, K Freude - Biomolecules, 2024 - mdpi.com
Today, neurodegenerative disorders like Alzheimer's disease (AD), Parkinson's disease
(PD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) affect millions …
(PD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) affect millions …
Mini-review:“ENTERIC GLIA FUNCTIONS IN NERVOUS TISSUE REPAIR: THERAPEUTIC TARGET OR TOOL?”
M Sunardi, C Cirillo - Neuroscience Letters, 2023 - Elsevier
In the body, nerve tissue is not only present in the central nervous system, but also in the
periphery. The enteric nervous system (ENS) is a highly organized intrinsic network of …
periphery. The enteric nervous system (ENS) is a highly organized intrinsic network of …
MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review
HMH Azam, RI Rößling, C Geithe, MM Khan… - Frontiers in Molecular …, 2024 - frontiersin.org
Neurodegenerative diseases (NDs) are characterized by abnormalities within neurons of the
brain or spinal cord that gradually lose function, eventually leading to cell death. Upon …
brain or spinal cord that gradually lose function, eventually leading to cell death. Upon …