Revisiting the critical roles of reactive astrocytes in neurodegeneration

K Qian, X Jiang, ZQ Liu, J Zhang, P Fu, Y Su… - Molecular …, 2023 - nature.com
Astrocytes, an integral component of the central nervous system (CNS), contribute to the
maintenance of physiological homeostasis through their roles in synaptic function, K+ …

Astrocytes: dissecting their diverse roles in amyotrophic lateral sclerosis and frontotemporal dementia

CF Valori, C Sulmona, L Brambilla, D Rossi - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal
neurodegenerative disorders often co-occurring in the same patient, a feature that suggests …

Emerging role of miR-21-5p in neuron–glia dysregulation and exosome transfer using multiple models of Alzheimer's disease

G Garcia, S Pinto, S Ferreira, D Lopes, MJ Serrador… - Cells, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder associated with neuron–glia
dysfunction and dysregulated miRNAs. We previously reported upregulated miR-124/miR …

Remodeling of astrocyte secretome in amyotrophic lateral sclerosis: uncovering novel targets to combat astrocyte-mediated toxicity

W Ng, SY Ng - Translational neurodegeneration, 2022 - Springer
Amyotrophic lateral sclerosis (ALS) is an adult-onset paralytic disease characterized by
progressive degeneration of upper and lower motor neurons in the motor cortex, brainstem …

Why should we care about astrocytes in a motor neuron disease?

K Stoklund Dittlau, L Van Den Bosch - Frontiers in Molecular …, 2023 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in adults,
causing progressive degeneration of motor neurons, which results in muscle atrophy …

Smart Nanoscale Extracellular Vesicles in the Brain: Unveiling their Biology, Diagnostic Potential, and Therapeutic Applications

A Onkar, F Khan, A Goenka… - … Applied Materials & …, 2024 - ACS Publications
Information exchange is essential for the brain, where it communicates the physiological and
pathological signals to the periphery and vice versa. Extracellular vesicles (EVs) are a …

Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43 A90V mutation display a mild reactive state and release polyP toxic to motoneurons

F Rojas, R Aguilar, S Almeida, E Fritz… - Frontiers in Cell and …, 2023 - frontiersin.org
Astrocytes play a critical role in the maintenance of a healthy central nervous system and
astrocyte dysfunction has been implicated in various neurodegenerative disorders, including …

Astrocytes: The Stars in Neurodegeneration?

K Stoklund Dittlau, K Freude - Biomolecules, 2024 - mdpi.com
Today, neurodegenerative disorders like Alzheimer's disease (AD), Parkinson's disease
(PD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) affect millions …

Mini-review:“ENTERIC GLIA FUNCTIONS IN NERVOUS TISSUE REPAIR: THERAPEUTIC TARGET OR TOOL?”

M Sunardi, C Cirillo - Neuroscience Letters, 2023 - Elsevier
In the body, nerve tissue is not only present in the central nervous system, but also in the
periphery. The enteric nervous system (ENS) is a highly organized intrinsic network of …

MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review

HMH Azam, RI Rößling, C Geithe, MM Khan… - Frontiers in Molecular …, 2024 - frontiersin.org
Neurodegenerative diseases (NDs) are characterized by abnormalities within neurons of the
brain or spinal cord that gradually lose function, eventually leading to cell death. Upon …