Shattering barriers toward clinically meaningful MSC therapies

O Levy, R Kuai, EMJ Siren, D Bhere, Y Milton… - Science …, 2020 - science.org
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …

Mesenchymal stem cells for neurological disorders

A Andrzejewska, S Dabrowska, B Lukomska… - Advanced …, 2021 - Wiley Online Library
Neurological disorders are becoming a growing burden as society ages, and there is a
compelling need to address this spiraling problem. Stem cell‐based regenerative medicine …

Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress

X Wu, J Jiang, Z Gu, J Zhang, Y Chen, X Liu - Stem cell research & …, 2020 - Springer
Mesenchymal stromal cells (MSCs) are a subset of heterogeneous non-hematopoietic
fibroblast-like cells that can differentiate into cells of multiple lineages, such as …

[HTML][HTML] Advancing application of mesenchymal stem cell-based bone tissue regeneration

F Shang, Y Yu, S Liu, L Ming, Y Zhang, Z Zhou, J Zhao… - Bioactive materials, 2021 - Elsevier
Reconstruction of bone defects, especially the critical-sized defects, with mechanical
integrity to the skeleton is important for a patient's rehabilitation, however, it still remains …

Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …

Clinical trials based on mesenchymal stromal cells are exponentially increasing: where are we in recent years?

U Galderisi, G Peluso, G Di Bernardo - Stem cell reviews and reports, 2022 - Springer
Mesenchymal stromal cells (MSCs), present in the stromal component of several tissues,
include multipotent stem cells, progenitors, and differentiated cells. MSCs have quickly …

Concise review: MSC-derived exosomes for cell-free therapy

DG Phinney, MF Pittenger - Stem cells, 2017 - academic.oup.com
Mesenchymal stem cell transplantation is undergoing extensive evaluation as a cellular
therapy in human clinical trials. Because MSCs are easily isolated and amenable to culture …

Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine

FJ Vizoso, N Eiro, S Cid, J Schneider… - International journal of …, 2017 - mdpi.com
Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to
their capacity for local engrafting and differentiating into multiple tissue types. However …

Intravascular mesenchymal stromal/stem cell therapy product diversification: time for new clinical guidelines

G Moll, JA Ankrum, J Kamhieh-Milz, K Bieback… - Trends in molecular …, 2019 - cell.com
Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal
stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has …

Paracrine mechanisms of mesenchymal stromal cells in angiogenesis

S Maacha, H Sidahmed, S Jacob… - Stem cells …, 2020 - Wiley Online Library
The role of the mesenchymal stromal cell‐(MSC‐) derived secretome is becoming
increasingly intriguing from a clinical perspective due to its ability to stimulate endogenous …