Synapses, as fundamental units of the neural circuitry, enable complex behaviors. The
neuromuscular junction (NMJ) is a synapse type that forms between motoneurons and …

The vertebrate neuromuscular junction (NMJ), a peripheral synapse formed between
motoneuron and skeletal muscle, is characterized by a protracted postnatal period of …

Neuromuscular junction (NMJ) formation requires agrin, a factor released from
motoneurons, and MuSK, a transmembrane tyrosine kinase that is activated by agrin …

The vertebrate neuromuscular junction (NMJ) remains the best‐studied model for
understanding the mechanisms involved in synaptogenesis, due to its relatively large size …

Prenyltransferases (PTases) are known to play a role in embryonic development, normal
tissue homeostasis and cancer by posttranslationally modifying proteins involved in these …

The differentiation of the neuromuscular junction is a multistep process requiring
coordinated interactions between nerve terminals and muscle. Although innervation is not …

Agrin, a motoneuron-derived factor, and the muscle-specific receptor tyrosine kinase (MuSK)
are essential for the acetylcholine receptor (AChR) clustering at the postjunctional …

Neurotransmission is ensured by a high concentration of neurotransmitter receptors at the
postsynaptic membrane. This is mediated by scaffold proteins that bridge the receptors with …

Agrin induces, whereas acetylcholine (ACh) disperses, ACh receptor (AChR) clusters during
neuromuscular synaptogenesis. Such counteractive interaction leads to eventual dispersal …

Wnt regulation of muscle development is thought to be mediated by the β-catenin-TCF/LEF-
dependent canonical pathway. Here we demonstrate that β-catenin, not TCF/LEF, is …