Neurodegenerative disorders are currently incurable devastating diseases which are
characterized by the slow and progressive loss of neurons in specific brain regions …

It has been proven that physical exercise improves cognitive function and memory, has an
analgesic and antidepressant effect, and delays the aging of the brain and the development …

Itaconate is produced by an enzyme encoded by the immune-responsive gene 1 (IRG1) and
exerts antibacterial, anti-inflammatory, and antioxidant effects via multiple mechanisms …

Tauopathies are a major type of proteinopathies underlying neurodegenerative diseases.
Mutations in the tau-encoding MAPT-gene lead to hereditary cases of frontotemporal lobar …

Parkinson's disease (PD) is a progressive neurodegenerative disorder induced by the loss
of dopaminergic neurons in midbrain. The mechanism of neurodegeneration is associated …

Alterations in function of hypoxanthine guanine phosphoribosyl transferase (HPRT), one of
the major enzymes involved in purine nucleotide exchange, lead to overproduction of uric …

The ataxia telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA
damage response and also an important sensor of oxidative stress. Analysis of gene …

Epilepsy is a neurological brain disease, and its recurrent seizures are related to the
reductive substance-powered antioxidant defense system (ADS). However, until now, there …

The brain is an organ that consumes a lot of energy. In the brain, energy is required for
synaptic transmission, numerous biosynthetic processes and axonal transport in neurons …

The brain's immune system plays a critical role in responding to immune challenges and
maintaining homeostasis. However, dysregulated neuroimmune function contributes to …